Atsushi Kittaka

Teikyo University

Japan

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Articles (11)

Year:

2024

Year:

2024

Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-chain was developed using N-fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary (26,27,30).

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Collaborators (4)

Makoto Makishima

Nihon University School of Medicine

JAPAN

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Daisuke Sawada

Okayama University

JAPAN

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Taro Matsumoto

Nihon University School of Medicine

JAPAN

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Kazuo Nagasawa

JAPAN

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Atsushi Kittaka

Research Interests

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Articles (11)

2α-Substituted Vitamin D Derivatives Effectively Enhance the Osteoblast Differentiation of Dedifferentiated Fat Cells

4-Hydroxy-1α,25-Dihydroxyvitamin D3: Synthesis and Structure–Function Study

Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination

Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism

Structure–activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052

The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities

Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D3 Derivatives: Stereoselectivity and Biological Activity

The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

Design and Synthesis of Fluoro Analogues of Vitamin D

Collaborators (4)

Makoto Makishima

Daisuke Sawada

Taro Matsumoto

Kazuo Nagasawa

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