Attila Ambrus

Full Professor

Semmelweis University

Hungary

Has grant

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Research Interests

Biochemistry

100%

Cell Biology

10%

Protein Chemistry

50%

Metabolic Biology

50%

Enzymology

40%

Molecular Biology

30%

Oxidative Stress

20%

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Recent Grants

Grant: Close

Structure elucidation of seven disease-causing variants of the human lipoamide dehydrogenase

Open Date: 2022-01-01

Close Date: 2022-12-01

Grant: Close

Structural investigation of the human alpha-ketoglutarate dehydrogenase enzyme complex

Open Date: 2022-01-01

Close Date: 2022-01-01

Grant: Close

Structure-function analysis of mitochondrial alpha-keto acid dehydrogenase complex mutations causing nervous system impairment

Open Date: 2022-01-01

Close Date: 2026-01-01

Grant: Close

Structure-function analysis of mitochondrial alpha-keto acid dehydrogenase complex mutations causing nervous system impairment

Open Date: 2021-11-01

Close Date: 2022-06-01

Grant: Close

Structure determination of the disease-causing mutants of the human dihydrolipoamide dehydrogenase

Open Date: 2021-01-01

Close Date: 2022-01-01

Articles11

Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase

Article Link

Year:

2023

Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation

Article Link

Year:

2023

Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase

Article Link

Year:

2023

Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants

Article Link

Year:

2023

Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency

Article Link

Year:

2023

Reverse and Forward Electron Flow-Induced H2O2 Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

Article Link

Year:

2022

Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid

Article Link

Year:

2022

Current Approaches in Molecular Enzymology

Article Link

Year:

2022

Methylene Blue Bridges the Inhibition and Produces Unusual Respiratory Changes in Complex III-Inhibited Mitochondria. Studies on Rats, Mice and Guinea Pigs

Article Link

Year:

2021

Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure

Article Link

Year:

2021

Hydrogen-Deuterium Exchange Mass Spectrometry: A Novel Structural Biology Approach to Structure, Dynamics and Interactions of Proteins and Their Complexes

Article Link

Year:

2020

Collaborators4

Frank Jordan

Rutgers University

UNITED STATES

Oliver Ozohanics

Semmelweis University

HUNGARY

Christos Chinopoulos

Semmelweis University

HUNGARY

Laszlo Tretter

Semmelweis University

HUNGARY

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