Aziz EL-AMRAOUI

Head of Unit « Progressive Sensory Disorders, Pathophysiology and Therapy"

Institut Pasteur

France

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About

Dr. Aziz El-Amraoui is the Head of the Unit for Progressive Sensory Disorders, Pathophysiology and Therapy at the Institut Pasteur in France. His research focuses on genetic factors influencing hearing and vision loss, with recent publications exploring gene therapy, genome editing, and the molecular mechanisms underlying Usher syndrome and progressive hearing loss. He is dedicated to advancing therapeutic strategies for sensory disorders through innovative approaches in genetics and biomedicine.

Articles (13)

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2025

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2024

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2024

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (5)

Sandrine Vitry

Assistant Professor

Institut Pasteur

FRANCE

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Kevin T. A. Booth

Indiana University School of Medicine

UNITED STATES

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Sedigheh Delmaghani

Assistant Professor

Institut Pasteur

FRANCE

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Franz Rüschendorf

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

GERMANY

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Karl Koehler

Assistant Professor

Harvard Medical School

UNITED STATES

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Aziz EL-AMRAOUI

Research Interests

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Articles (13)

How a gene fuels ear infections.

Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss

Direct delivery of Cas9 or base editor protein and guide RNA complex enables genome editing in the retina.

The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification

Vestibular Deficits in Deafness: Clinical Presentation, Animal Modeling, and Treatment Solutions

Usher syndrome Recent advances in our understanding of genes and therapeutics

Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art.

A biallelic variant in CLRN2 causes non-syndromic hearing loss in humans

Progress in Gene Editing Tools and Their Potential for Correcting Mutations Underlying Hearing and Vision Loss.

Review of Genotype-Phenotype Correlations in Usher Syndrome.

Inner Ear Gene Therapies Take Off: Current Promises and Future Challenges

Disease mechanisms and gene therapy for Usher syndrome

Identification of a CDH12 potential candidate genetic variant for an autosomal dominant form of transgrediens and progrediens palmoplantar keratoderma in a Tunisian family

Collaborators (5)

Sandrine Vitry

Kevin T. A. Booth

Sedigheh Delmaghani

Franz Rüschendorf

Karl Koehler

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