Bahaa Elgendy

Associate Professor

United States

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Bahaa Elgendy is an Associate Professor at Washington University School of Medicine and St. Louis College of Pharmacy. His research focuses on mitochondrial therapeutics, specifically the development of inhibitors targeting the mitochondrial pyruvate carrier and the synthesis of anti-inflammatory agents. His recent publications include advancements in therapeutic applications for mitochondrial dysfunction and innovative synthetic approaches for anticancer and anti-inflammatory compounds.

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Arindam Chatterjee

Assistant Professor

Notre Dame of Maryland University

UNITED STATES

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Kristine Griffett

Assistant Professor

Auburn University

UNITED STATES

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Bahaa Elgendy

Research Interests

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Articles (20)

Advances in the Development of Mitochondrial Pyruvate Carrier Inhibitors for Therapeutic Applications

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C–H activation: development of synthetic TLX agonists

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

2,5-Diketopiperazines (DKPs): Promising Scaffolds for Anticancer Agents

Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights

Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.

4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB

Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists

Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

Synthesis and structure activity relationship of the first class of LXR inverse agonists

Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.

Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.

Collaborators (8)

Kevin Cho

Kyle McCommis

Brian Finck

Matthew Hayes

Ewa Krawczyk

Thomas P. Burris

Arindam Chatterjee

Kristine Griffett

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