Beate Rinner

Medical University of Graz

Austria

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Articles (11)

Year:

2024

Year:

2022

Year:

2021

Year:

2021

Year:

2021

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2021

Year:

2021

Year:

2021

Silibinin is an herbal polyphenol with high antioxidant and anticancer properties. In this study, its influence on U-CH2 (human sacral chordoma cell line) and MCF-7 (human breast adenocarcinoma cell line) cells was investigated and compared. We analyzed real-time cell viability by xCELLigence system. It was found that the cytotoxic effect of silibinin began about 10 hours after administration. Silibinin differentially influenced MCF-7 and U-CH2 cells and caused decrease in the cell index value of MCF-7 cells more than U-CH2 cells (more than 2 times) at 24 h. This suggests that silibinin is a promising drug for breast cancer but less favorable for chordoma.

Year:

2021

Year:

2021

Year:

2021

Collaborators (23)

Melanie Korbelius

Medical University of Graz

AUSTRIA

Beate Rinner

Research Interests

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Articles (11)

Detection of a Water-Soluble Hypericin Formulation in Glioblastoma Tissue with Fluorescence Lifetime and Intensity Using a Dual-Tap CMOS Camera System

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model

Global analysis of protein arginine methylation

MUG Mel3 Cell Lines Reflect Heterogeneity in Melanoma and Represent a Robust Model for Melanoma in Pregnancy

Effect of L- to D-Amino Acid Substitution on Stability and Activity of Antitumor Peptide RDP215 against Human Melanoma and Glioblastoma

Polymer Coated Oncolytic Adenovirus to Selectively Target Hepatocellular Carcinoma Cells

Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump

Evaluation of Silibinin Effect on U-CH2 and MCF-7 Cell Lines through xCELLigence System

Drug combination screening as a translational approach toward an improved drug therapy for chordoma

Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma

Collaborators (23)

Melanie Korbelius

Angelika Unterhuber

Ellen Heitzer

Linda Waldherr

Rainer Schindl

Magdalena Wieczorek

Brigitte Pertschy

Rainer Leitgeb

Nadine Kretschmer

Marco Andreana

Georg Widhalm

Martin Pichler

Ulrich Stelzl

Birgit Lohberger

Francesca Mastrotto

Jelena Krstic

Mariangela Garofalo

Katarzyna Pancer

Dagmar Zweytick

Tobias Madl

Marta Nowakowska

Maria J. Rodriguez-Colman

Christian Wadsack

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