Benjamin Cons

Astex Pharmaceuticals

United Kingdom

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Articles (9)

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Collaborators (5)

John Lunec

UNITED KINGDOM

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Celine Cano

Reader in Medicinal Chemistry

Newcastle University

UNITED KINGDOM

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Alastair Lennox

University of Bristol

UNITED KINGDOM

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Steve Wedge

Newcastle University

UNITED KINGDOM

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Jane Endicott

Prof of Cancer Structural Biology

Newcastle University

UNITED KINGDOM

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Benjamin Cons

Research Interests

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Articles (9)

Alkene 1,3-Difluorination via Transient Oxonium Intermediates

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase

Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions

Electrostatic Complementarity in Structure-Based Drug Design

Electrostatic Complementarity in Structure-Based Drug Design

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Collaborators (5)

John Lunec

Celine Cano

Alastair Lennox

Steve Wedge

Jane Endicott

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