Brahma Ghosh

Senior Principal Scientist, Head- Chemical Biology

United States

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Dr. Brahma Ghosh is a Senior Principal Scientist and Head of Chemical Biology at Johnson & Johnson, USA. His research focuses on chemical proteomics, target engagement, and the development of novel therapeutic strategies, as highlighted in his recent publications. Dr. Ghosh's work includes studies on inhibitors for dengue virus, the application of AlphaFold models in drug discovery, and the characterization of chemical probes for modulating protein complexes in human cells.

Articles (8)

Year:

2024

Year:

2024

Year:

2024

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2023

Year:

2023

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2021

Year:

2021

Year:

2020

Collaborators (3)

Thomas Hangian

Assistant Professor

University of Houston

UNITED STATES

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Paramjit S. Arora

UNITED STATES

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Gene W Yeo

University of California, San Diego

UNITED STATES

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Brahma Ghosh

Research Interests

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Articles (8)

Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation

Application of AlphaFold models in evaluating ligandable cysteines across E3 ligases

End-to-End Throughput Chemical Proteomics for Photoaffinity Labeling Target Engagement and Deconvolution

Remodeling oncogenic transcriptomes by small molecules targeting NONO

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics

Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

Collaborators (3)

Thomas Hangian

Paramjit S. Arora

Gene W Yeo

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