Brandon Garcia

Associate Professor

University of Kansas

United States

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Brandon Garcia is an Associate Professor at Kansas State University in the United States. His research focuses on complement regulation and inhibition, particularly involving the C1r and C1s proteases, as well as the role of pirin proteins in bacterial metabolism and antimicrobial susceptibility. Recent publications include investigations into the molecular determinants of complement inhibition by Borrelia burgdorferi proteins and the membrane-binding properties of lipoxygenases.

Articles (10)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

Collaborators (4)

Samuel Bouyain

Professor

University of Missouri Kansas City

UNITED STATES

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Adam Offenbacher

East Carolina University

UNITED STATES

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Wolfram R. Zückert

UNITED STATES

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Mark Mannie

Professor

East Carolina University

UNITED STATES

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Brandon Garcia

Research Interests

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Articles (10)

Blocking activation of the C1r zymogen defines a novel mode of complement inhibition

The Crystal Structure of the Michaelis–Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation

New functions of pirin proteins and a 2‐ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile

The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi

Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs

Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25high regulatory and memory T cells

Investigating membrane-binding properties of lipoxygenases using surface plasmon resonance

Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease– and relapsing fever–causing spirochetes

Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing

Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s

Collaborators (4)

Samuel Bouyain

Adam Offenbacher

Wolfram R. Zückert

Mark Mannie

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