Breandan Kennedy

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Professor

Dublin City University

Ireland

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About

Professor Breandan Kennedy is a faculty member at University College Dublin, Ireland. His research focuses on cancer biology, retinal diseases, and novel therapeutic agents, as evidenced by his recent publications on quininib prodrugs, zebrafish models for vision impairment, and targeting resistance mechanisms in cancer. He employs a range of methodologies to explore the molecular underpinnings of these conditions and their potential treatments.

Recent Grants

Grant: Close

Frontiers in Ocular Therapeutics

Open Date: 2015-09-01

Close Date: 2016-02-29

Grant: Close

Developing Intravitreal Microparticles as a DeliveryMechanism for Small Molecule Inhibitors of OcularNeovascularisation and Inflammation

Open Date: 2015-01-01

Close Date: 2015-12-31

Grant: Close

Developing Intravitreal Microparticles as a Delivery Mechanism for Small Molecule Inhibitors of Ocular Neovascularisation and Inflammation

Open Date: 2014-01-01

Close Date: 2015-11-30

Grant: Close

SFI Internship Award

Open Date: 2013-03-25

Close Date: 2014-03-24

Grant: Close

Development of Novel Inhibitors of Ocular Neovascularisation

Open Date: 2012-01-01

Close Date: 2013-09-30

Articles (22)

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2022

Collaborators (10)

Tess McCann

University College Dublin

IRELAND

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Niamh O'Sullivan

Associate Professor

Dublin City University

IRELAND

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Chiara Gabellini

University of Pisa

ITALY

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Roxana Radu

Professor of Ophthalmology

Stein Eye Institute, UCLA

UNITED STATES

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Desmond J. Tobin

Dublin City University

IRELAND

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VITTORIA RAFFA

Associate Professor

University of Pisa

ITALY

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Kayleigh Slater

Dublin City University

IRELAND

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Memona KHAN

Sorbonne Université

FRANCE

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Stephen G. Maher

Trinity College Dublin

IRELAND

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William Watson

Full Professor of Cancer Biology

Dublin City University

IRELAND

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Breandan Kennedy

Research Interests

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About

Recent Grants

Articles (22)

Germline Disruption of Retinal Pigment Epithelium‐Expressed Zebrafish rlbp1b−/− Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants

The Dark and Bright Sides Of Retinal G Protein-Coupled Receptor (RGR) in Vision and Disease

Characterization of a water soluble quininib prodrug that blocks metabolic activity and proliferation of multiple cancer cell lines

Evaluating TnP as a Potential Therapeutic Agent for Retinopathy in Zebrafish Models

Novel in vivo models of autosomal optic atrophy reveal conserved pathological changes in neuronal mitochondrial structure and function

Uncovering Novel Drugs that Restore Vision Using Orthogonal Pooling in Zebrafish

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature

Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy

Targeting Radiation Resistance in Oesophageal Adenocarcinoma with Pyrazinib-Functionalised Gold Nanoparticles

Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Gene therapy for RAB28: What can we learn from zebrafish?

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Regulation of the rhythmic diversity of daily photoreceptor outer segment phagocytosis in vivo

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products.

Collaborators (10)

Tess McCann

Niamh O'Sullivan

Chiara Gabellini

Roxana Radu

Desmond J. Tobin

VITTORIA RAFFA

Kayleigh Slater

Memona KHAN

Stephen G. Maher

William Watson

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