Brent Hanks

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Associate Professor

Duke Medicine

United States

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About

Brent Hanks is an Associate Professor at Duke Medicine in the United States. His research areas encompass the therapeutic potential of the cGAS–STING pathway, the management of microsatellite instability high gastroesophageal adenocarcinoma, and tumor immune evasion mechanisms. Dr. Hanks' recent publications focus on the intricate roles of dendritic cells in cancer progression, the implications of neoadjuvant therapy in melanoma, and the effects of COVID-19 on cancer care.

Recent Grants

Grant: Close

MDSC Recruitment as an Adaptive Resistance Mechanism to PD-1 Ab Therapy

Open Date: 2017-05-15

Close Date: 2019-05-14

Grant: Close

Melanoma-mediated Dendritic Cell Tolerization and Immune Evasion

Open Date: 2015-08-04

Close Date: 2020-07-31

Grant: Close

Inhibiting the TGF-ß Signaling Axis in the Melanoma Microenvironment

Open Date: 2013-11-01

Close Date: 2017-01-31

Grant: Close

Role of Type III TGF-Beta Receptor in Mediating Immunosuppression during Breast Cancer Progression

Open Date: 2008-10-01

Close Date: 2009-09-01

Articles (15)

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2025

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2022

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2022

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2022

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2022

Collaborators (6)

Michael Plebanek

University of North Carolina, Lineberger Comprehensive Cancer Center

UNITED STATES

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Xiaodi Qin

Duke University

UNITED STATES

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Elizabeth Mendes

Duke University

UNITED STATES

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Alexander Broom

Professor of Sociology

University of Sydney

AUSTRALIA

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Georgia Beasley

Associate Professor

Duke University School of Medicine

UNITED STATES

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Alexander Page

James Cook University

AUSTRALIA

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Brent Hanks

Research Interests

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About

Recent Grants

Articles (15)

Unlocking the Therapeutic Potential of the cGAS–STING Pathway through TREX1 Targeting

A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression

Management of Microsatellite Instability High (MSI-H) Gastroesophageal Adenocarcinoma

Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling

The Enduring Effects of COVID for Cancer Care: Learning from Real-Life Clinical Practice

A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression

A SREBF2-dependent genetic program drives a novel immunotolerant dendritic cell population that supports cancer progression

Multicenter Experience with Neoadjuvant Therapy in Melanoma Highlights Heterogeneity in Contemporary Practice

The “Inside” Story on Tumor-Expressed PD-L1

APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell–Mediated Antitumor Immune Responses

Clinical Trials with Biologic Primary Endpoints in Immuno-oncology: Concepts and Usage

ACTIVITY OF THE TUMOR-INTRINSIC NLRP3 INFLAMMASOME PATHWAY PREDICTS FOR RESPONSE TO CHECKPOINT INHIBITOR IMMUNOTHERAPY IN MELANOMA PATIENTS

Editorial: Signaling pathways behind immune evasion and therapy resistance

Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multiple Spontaneous Regressions and Immune-related Adverse Events

Molecular classification of cancers of unknown primary expands and refines treatment options

Collaborators (6)

Michael Plebanek

Xiaodi Qin

Elizabeth Mendes

Alexander Broom

Georgia Beasley

Alexander Page

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