Brian Clark

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Assistant Professor

Washington University in Saint Louis School of Medicine

United States

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About

Brian Clark is an Assistant Professor at Washington University in Saint Louis School of Medicine, United States. His research focuses on retinal development and the molecular mechanisms underlying retinal diseases, as evidenced by his recent articles on DNA demethylation and retinal transcriptome dysregulation. Additionally, he investigates the roles of neural progenitors in vision restoration and corneal epithelial regeneration.

Recent Grants

Grant: Close

Identification of the molecular mechanisms mediating intrinsic control of retinal progenitor competence

Open Date: 2017-04-01

Close Date: 2019-03-31

Grant: Close

Identification of the molecular mechanisms mediating intrinsic control of retinal progenitor competence

Open Date: 2017-04-01

Close Date: 2022-05-31

Grant: Close

Regulation of Retinal Progenitor Cell Competence by Long noncoding RNAs

Open Date: 2014-04-01

Close Date: 2017-03-31

Articles (14)

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2025

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (14)

Ferhat Ay

Associate Professor

UNITED STATES

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John Kessler

Professor

Northwestern University

UNITED STATES

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Pierre Mattar

CANADA

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Abhinav Nellore

Assistant Professor

Oregon Health & Science University

UNITED STATES

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Xuewei Wang

Assistant Professor

University of South Florida

UNITED STATES

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Ephraim F. Trakhtenberg

UNITED STATES

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Karolinska Institutet

SWEDEN

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Brian Clark

Research Interests

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About

Recent Grants

Articles (14)

Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development.

Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains

Age‐related dysregulation of the retinal transcriptome in African turquoise killifish

Age-related dysregulation of the retinal transcriptome in African turquoise killifish.

Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq

Atoh7-independent specification of retinal ganglion cell identity

A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.

Atoh7-independent specification of retinal ganglion cell identity

ASCOT identifies key regulators of neuronal subtype-specific splicing

Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP–Smad signaling

Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.

Collaborators (14)

Ferhat Ay

John Kessler

Pierre Mattar

Abhinav Nellore

Xuewei Wang

Ephraim F. Trakhtenberg

Luis Alarcon-Martinez

Jonathan Ling

Thomas Johnson

Philip Ruzycki

William Spencer

Pratheepa kumari Rasiah

Benjamin Langmead

James Tribble

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