Brian D Strahl

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Professor and Vice-Chair

UNC Health Care System

United States

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Brian D Strahl is a Professor and Vice-Chair at the UNC Health Care System in the United States. His research focuses on the roles of histone modifications in gene regulation and cellular processes, as demonstrated in his recent publications. His work includes significant findings on the regulation of tumorigenesis in lung cancer models and the dynamics of nucleosome positioning during transcription.

Recent Grants

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Chromatin maintenance in cancer progression

Open Date: 2015-09-30

Close Date: 2020-08-31

Grant: Close

Factors that regulate chromatin organization and gene transcription

Open Date: 2014-06-01

Close Date: 2018-02-28

Grant: Close

Engineering histone genes to interrogate the epigenetic code in space and time

Open Date: 2013-09-15

Close Date: 2018-05-31

Articles (17)

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2025

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2022

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2021

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North Carolina State University

UNITED STATES

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Brian D Strahl

Research Interests

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About

Recent Grants

Articles (17)

SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

Spt6-Spn1 interaction is required for RNA polymerase II association and precise nucleosome positioning along transcribed genes

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Histone H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment

Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression

The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation

Author Correction: Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

In Memoriam C. David Allis: Chromatin unlocked

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster

Mechanically transduced immunosorbent assay to measure protein-protein interactions

Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors

Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14

Oncohistones: corruption at the core

Catalysis-dependent and redundant roles of Dma1 and Dma2 in maintenance of genome stability in Saccharomyces cerevisiae

Collaborators (10)

A. Gregory Matera

Sarah Peck Justice

Joseph Harrison

Robert Dowen

Kanishk Jain

Daniel McKay

Austin Hepperla

Stephen Klusza

Venkat R Chirasani

Robert Rose

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