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Brian Huntly

Has grant

Head of Department

University of Cambridge

United Kingdom

Research Interests

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Recent Grants

Grant: Open

Identification of mechanisms of transformation and therapeutic vulnerabilities for the DNMT3A-R882 mutation across the continuum of myeloid neoplasia

Open Date: 2026-01-01

Close Date: 2028-12-01

Grant: Open

Mechanisms of HOXA9 regulation, transformation and targeting

Open Date: 2025-09-01

Close Date: 2028-08-01

Grant: Open

Development of a clinical program for myeloid cancer prevention

Open Date: 2024-02-01

Close Date: 2029-01-01

Grant: Close

Stroboscopic opto-acoustic scattering (SOAS) flow cytometer for pre-cancerous detection

Open Date: 2023-06-30

Close Date: 2025-02-28

Grant: Open

The role of mutational synergy and oncogenic signalling to chromatin in initiation, maintenance and disease resistance in Acute Myeloid Leukaemia (AML)

Open Date: 2023-06-01

Close Date: 2028-05-31

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Collaborators (18)

Jesús María Hernández-Rivas

Universidad de Salamanca

SPAIN

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Klaus Metzeler

Professor of Translational Hematology

Leipzig University

GERMANY

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ROSA MARIA AYALA DIAZ

Full Professor

Universidad Complutense de Madrid

SPAIN

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Konstantinos Tzelepis

Principal Investigator

University of Cambridge

UNITED KINGDOM

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Shuchi Agrawal Singh

Group Leader / Lecturer

Imperial College London

UNITED KINGDOM

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Frederik Damm

Charité - Universitätsmedizin Berlin

GERMANY

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Véronique De Mas

Institut Universitaire du Cancer de Toulouse

FRANCE

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Jelena Jovanovic

King’s College London

UNITED KINGDOM

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Katherine Stott

University of Cambridge

UNITED KINGDOM

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Daniel Prins

Staff Scientist

National Institutes of Health

UNITED STATES

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Mikkel-Ole Skjødt

Københavns Universitet

DENMARK

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Michael W. M Kühn

Professor of Medicine

University Medical Center of the Johannes Gutenberg University Mainz

GERMANY

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Aristi Damaskou

University of Cambridge

UNITED KINGDOM

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Paolo Gallipoli

Clinical Reader in Experimental Haematology

Queen Mary University of London

UNITED KINGDOM

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Sylvie Freeman

University of Birmingham

UNITED KINGDOM

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James Alexander Nathan

Wellcome Senior Clinical Research Fellow, Professor of Respiratory Medicine, Honorary Consultant Physician

University of Cambridge

UNITED KINGDOM

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Lars Bullinger

Charité University Medicine

GERMANY

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Carolin Sauer

Group Leader

Vall d'Hebron Institute of Oncology

SPAIN

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Brian Huntly

Research Interests

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Recent Grants

Articles (20)

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.

Multimodal and Data-Driven Assessment of Myeloid Neoplasms Refines Classification across Disease States.

Gene regulatory complexes: their role and regulation across normal and malignant hematopoiesis

Epigenetic dysregulation in acute myeloid leukemia.

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.

Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML

Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Novel immunotherapeutics against LGR5 to target multiple cancer types

Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance.

Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study

Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types

Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting.

Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression

Integrated functional genomic screening to bypass TKI resistance in chronic myeloid leukemia.

Precision hematology: Navigating the evolution of diagnostic classifications in the era of globalized medicine.

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.

A guide to epigenetics in leukaemia stem cells

Collaborators (18)

Jesús María Hernández-Rivas

Klaus Metzeler

ROSA MARIA AYALA DIAZ

Konstantinos Tzelepis

Shuchi Agrawal Singh

Frederik Damm

Véronique De Mas

Jelena Jovanovic

Katherine Stott

Daniel Prins

Mikkel-Ole Skjødt

Michael W. M Kühn

Aristi Damaskou

Paolo Gallipoli

Sylvie Freeman

James Alexander Nathan

Lars Bullinger

Carolin Sauer

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