Brian Luke

Professor

Johannes Gutenberg Universität Mainz

Germany

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Professor Brian Luke is a faculty member at Johannes Gutenberg Universität Mainz, Germany. His research primarily focuses on molecular genetics, with recent articles exploring the roles of R-loops in telomere maintenance and genomic stability, as well as the mechanisms underlying DNA repair in eukaryotic cells. He contributes to the understanding of how non-coding RNAs and chromatin modifications impact cellular responses to genotoxic stress and replication challenges.

Articles (10)

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2025

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2025

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2022

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2022

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (3)

Martin Möckel

Head of Protein Production

Institute of Molecular Biotechnology

GERMANY

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Félix Prado

SPAIN

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Vassilis Roukos

Assistant Professor

University of Patras

GREECE

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Brian Luke

Research Interests

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Articles (10)

RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres

Genome-wide conditional degron libraries for functional genomics

TERRA increases at short telomeres in yeast survivors and regulates survivor associated senescence (SAS)

Transcription of ncRNAs promotes repair of UV induced DNA lesions in Saccharomyces cerevisiae subtelomeres

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability.

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents

Npl3 stabilizes R‐loops at telomeres to prevent accelerated replicative senescence

Regulatory R-loops as facilitators of gene expression and genome stability

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

Collaborators (3)

Martin Möckel

Félix Prado

Vassilis Roukos

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