Bruce Russell
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Recent Grants
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Walking backwards into the future: An evolutionary investigation into the high rates of metabolic disease in Pacific populations
Open Date: 2020-01-01
Close Date: 2023-01-01
Grant: Close
Unraveling the molecular basis for vivax malaria's unhealthy attraction to human reticulocytes
Open Date: 2018-01-01
Close Date: 2021-01-01
Articles (14)
Extended blood stage sensitivity profiles of <i>Plasmodium cynomolgi</i> to doxycycline and tafenoquine, as a model for <i>Plasmodium vivax</i>
Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax , we determined the physiologically significant delayed death effect induced by doxycycline [IC 50(96 h) , 1,401 ± 607 nM]. As expected, IC 50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 µM), and tafenoquine (1,424 nM) were not affected by extended exposure.
Year:
2024
Collaborators (9)
Sergio Romeo
Associate Professor
Università degli Studi di Torino
Donatella Taramelli
Full Professor of Pathology
University of Milan
SILVIA PARAPINI
Associate Professor in Biotechnology and Methods in Laboratory Medicine
University of Milan
Sarah Auburn
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Benoit Malleret
Assistant Professor
National University of Singapore (NUS)
Laurent Renia
Professor of Infectious Diseases
Lee Kong Chian School of Medicine, Nanyang Technological University
Anna Sparatore
Full Professor
Università degli Studi di Torino
Osamu Kaneko
Dean
Institute of Tropical Medicine, Nagasaki University
Gabriela Minigo
Charles Darwin University
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