Campbell McInnes

Professor

University of South Carolina

United States

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About

Campbell McInnes is a Professor at the University of South Carolina, USA. His research focuses on cell cycle regulation, particularly in relation to PLK1 activity and its implications for drug discovery. Recent publications explore structural mechanisms of PLK1 inhibitors and strategies to overcome resistance to FLT3-ITD therapeutics.

Articles (6)

Year:

2025

Year:

2024

Year:

2023

Year:

2022

Year:

2021

Year:

2020

Collaborators (3)

Klaus Strebhardt

Research Head

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt

GERMANY

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Michael D. Wyatt

UNITED STATES

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Cecilia Hurtado

UNITED STATES

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Campbell McInnes

Research Interests

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Articles (6)

Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery

Overcoming Resistance to FLT3-ITD Therapeutics

Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors

Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE

Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells

Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor

Collaborators (3)

Klaus Strebhardt

Michael D. Wyatt

Cecilia Hurtado

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