Catherine A. Christian-Hinman

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Associate Professor

University of Illinois at Urbana-Champaign

United States

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Dr. Catherine A. Christian-Hinman is an Associate Professor at the University of Illinois Urbana-Champaign. Her research areas include the interactions of sex as a biological variable in epilepsy, the role of mGluR7 in Fragile X Syndrome, and the modulation of synaptic activity by the adrenergic system in the hippocampus. She has published extensively on topics such as the impact of the ovarian cycle in preclinical research and the effects of gonadectomy on seizure susceptibility. Dr. Christian-Hinman's work contributes valuable insights into neurological disorders and reproductive endocrine dysfunction.

Recent Grants

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Developing a mouse model of hypothalamic hamartoma

Open Date: 2022-03-01

Close Date: 2023-02-01

Grant: Close

Differential roles of neuronal and astrocytic aromatase in status epilepticus and chronic epilepsy

Open Date: 2021-09-30

Close Date: 2023-02-28

Grant: Close

Lateralized targeting of hippocampus to model interactions between epilepsy and reproductive endocrine disorders

Open Date: 2018-07-15

Close Date: 2020-06-30

Grant: Close

Neural and pituitary mechanisms linking epilepsy to co-morbid reproductive endocrine dysfunction

Open Date: 2018-04-01

Close Date: 2023-03-31

Grant: Close

Astrocytic Modulation of Synaptic Inhibition

Open Date: 2016-01-01

Close Date: 2019-01-01

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2020

Collaborators (4)

Hee Jung Chung

Associate Professor

University of Illinois at Urbana-Champaign

UNITED STATES

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Carlos Renteria

National Institute of Standards and Technology

UNITED STATES

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Maltesh Kambali

University of Illinois Urbana–Champaign

UNITED STATES

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Nien‐Pei Tsai

UNITED STATES

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Catherine A. Christian-Hinman

Research Interests

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About

Recent Grants

Articles (20)

The Promise and Practicality of Addressing Sex as a Biological Variable and the Ovarian Cycle in Preclinical Epilepsy Research.

mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS.

Optoα1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner.

Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning.

Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.

Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment.

Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research.

Sex and Estrous Cycle Stage Shape Left-Right Asymmetry in Chronic Hippocampal Seizures in Mice.

Female-specific pituitary gonadotrope dysregulation in mice with chronic focal epilepsy.

Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.

Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption.

Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of K<sub>v</sub>7.2.

From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.

Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling.

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.

Simultaneous two-photon activation and imaging of neural activity based on spectral-temporal modulation of supercontinuum light.

Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy.

Is On-Demand Dynorphin Destined to Be in Demand to Decrease Seizures?

Assessin' the Vexin' Connexin Between Severity of Epilepsy and Hippocampal Gliosis.

A Single Test to Study Social Behavior and Repetitive Self-grooming in Mice

Collaborators (4)

Hee Jung Chung

Carlos Renteria

Maltesh Kambali

Nien‐Pei Tsai

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