Celine Lefebvre

Head of Computational Medicine

Institut de recherches Servier

France

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About

Dr. Celine Lefebvre is the Head of Computational Medicine at Institut de recherches Servier in France. Her research focuses on immunometabolic modulation in cancer, T cell activation, and the application of AI in drug discovery. Recent articles reflect her expertise in cancer immunotherapy, primary Sjögren's disease, and the neurobiological effects of HIV.

Articles (9)

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2025

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2024

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2024

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2024

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2024

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2023

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2022

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2022

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2021

Collaborators (5)

Federico Giorgi

Associate Professor

University of Bologna

ITALY

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Laurence Laigle

Head of biomarker strategy in immuno-inflammatory diseases

FRANCE

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Daniele Mercatelli

Junior Assistant Professor

University of Bologna

ITALY

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Philippe Moingeon

Head

FRANCE

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Giordano de Guglielmo

Assistant Professor

University of California, San Diego

UNITED STATES

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Celine Lefebvre

Research Interests

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Articles (9)

Glucose deprivation and identification of TXNIP as an immunometabolic modulator of T cell activation in cancer.

The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells.

In silico and pharmacological evaluation of GPR65 as a cancer immunotherapy target regulating T-cell functions.

Consensus gene modules strategy identifies candidate blood-based biomarkers for primary Sjögren's disease.

Characterization of CD4+ and CD8+ T cells responses in the mixed lymphocyte reaction by flow cytometry and single cell RNA sequencing.

Transforming drug discovery with a high-throughput AI-powered platform: A 5-year experience with Patrimony

Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats

Industrializing AI-powered drug discovery: lessons learned from the Patrimony computing platform

Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individuals.

Collaborators (5)

Federico Giorgi

Laurence Laigle

Daniele Mercatelli

Philippe Moingeon

Giordano de Guglielmo

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