Chang Liu

Professor and Chancellor's Fellow

University of California, Irvine

United States

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About

Chang Liu is a Professor and Chancellor's Fellow at the University of California Irvine, USA. His research focuses on protein interactions, antibody fragment polyreactivity, and the development of advanced CRISPR technologies. He has made significant contributions to the fields of enzyme optimization and small-molecule biosensors through innovative experimental methods and continuous directed evolution.

Articles (10)

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (2)

Eric Sweet-Cordero

Professor

University of California, San Francisco

UNITED STATES

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Laura Wingler

Assistant Professor

Duke University

UNITED STATES

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Chang Liu

Research Interests

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Articles (10)

Discovery of VH domains that allosterically inhibit ENPP1

Learning to Read and Write in the Language of Proteins

An in silico method to assess antibody fragment polyreactivity

What are the current bottlenecks in developing and applying CRISPR technologies?

In vivo hypermutation and continuous evolution

Using continuous directed evolution to improve enzymes for plant applications

Rapid generation of potent antibodies by autonomous hypermutation in yeast.

Integrating continuous hypermutation with high‐throughput screening for optimization of <i>cis,cis</i>‐muconic acid production in yeast

Evolving Small-Molecule Biosensors with Improved Performance and Reprogrammed Ligand Preference Using OrthoRep

Systems for in vivo hypermutation: a quest for scale and depth in directed evolution

Collaborators (2)

Eric Sweet-Cordero

Laura Wingler

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