chao zheng

Assistant Professor

University of Toronto

Canada

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Chao Zheng is an Assistant Professor at the University of Toronto, Canada. His research centers on neurodegenerative diseases, particularly Alzheimer's disease, and includes the development of therapeutic compounds and imaging agents for the assessment of tau protein and synaptic functions. Recent articles highlight his work on S,N-heterocyclic compounds, silybin derivatives for diabetes mellitus, and innovative coupling reactions, contributing significantly to the fields of medicinal chemistry and neurobiology.

Articles (14)

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2025

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2025

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2025

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (2)

Liang Shi

University of California

UNITED STATES

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Jeff Stehouwer

UNITED STATES

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chao zheng

Research Interests

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Articles (14)

Multi-Fused S,N-Heterocyclic Compounds for Targeting α-Synuclein Aggregates

Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions

Radiosynthesis, In Vitro Characterization, and In Vivo PET Neuroimaging of [18F]F-4 for Tau Protein: A First-in-Human PET Study

Structure-Guided Discovery of Subtype Selective SIRT6 Inhibitors with a β-Carboline Skeleton for the Treatment of Breast Cancer

Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16

Copper-catalyzed umpolung Sonogashira-type coupling of arene boronic acids under visible light

Copper-catalyzed umpolung Sonogashira-type coupling of arene boronic acids under visible light

Visualization of synaptic vesicle protein 2A in a rodent model of familial Alzheimer’s disease with a metabolically stable PET probe

Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research

β-Amyloid Peptides Manipulate Switching Behaviors of Donor–Acceptor Stenhouse Adducts

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16

Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones

Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase

Collaborators (2)

Liang Shi

Jeff Stehouwer

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