Charles Carter

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University of North Carolina at Chapel Hill School of Medicine

United States

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Charles Carter is a Professor at the University of North Carolina at Chapel Hill School of Medicine in the United States. His research interests include structural enzymology, phylogenetics, and the evolution of genetic coding. Recent articles authored by Professor Carter explore topics such as amino acid substitution matrices, the optimization of aminoacyl-tRNA synthetases through deep learning, and the self-organization of genetic coding.

Recent Grants

Grant: Close

Storage and Recovery of ATP binding energy in Metal-Catalyzed Phosphoryl-Transfer

Open Date: 2010-09-01

Close Date: 2015-06-30

Grant: Close

Sense/Antisense Genetic Coding and the Origins of Translation

Open Date: 2006-08-01

Close Date: 2019-05-31

Articles (19)

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2020

Collaborators (4)

Peter Wills

Associate Professor

University of Auckland Faculty of Science

NEW ZEALAND

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George Phillips

Professor

Rice University

UNITED STATES

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Nikolay Dokholyan

G. Thomas Passananti Professor, Vice Chair for Research

Penn State College of Medicine

UNITED STATES

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Simon Harris

Associate Professor of Probability

University of Auckland

NEW ZEALAND

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Charles Carter

Research Interests

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About

Recent Grants

Articles (19)

Reduced Amino Acid Substitution Matrices Find Traces of Ancient Coding Alphabets in Modern Day Proteins

Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology

Evolution is coupled with branching across many granularities of life

Aminoacyl-tRNA synthetase urzymes optimized by deep learning behave as a quasispecies

Whither the protein landscape?

HetMM: A Michaelis-Menten model for non-homogeneous enzyme mixtures

Enzymic recognition of amino acids drove the evolution of primordial genetic codes

A genomic database furnishes minimal functional glycyl-tRNA synthetases homologous to other, designed class II urzymes

Primordial aminoacyl-tRNA synthetases preferred minihelices to full-length tRNA

Base Pairing Promoted the Self-Organization of Genetic Coding, Catalysis, and Free-Energy Transduction

Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs

High-throughput thermal denaturation of tryptophanyl-tRNA synthetase combinatorial mutants reveals high-order energetic coupling determinants of conformational stability

Microcalorimetry reveals multi-state thermal denaturation of G. stearothermophilus tryptophanyl-tRNA synthetase

A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP

Multidimensional Phylogenetic Metrics Identify Class I Aminoacyl-tRNA Synthetase Evolutionary Mosaicity and Inter-Modular Coupling

Simultaneous codon usage, the origin of the proteome, and the emergence of de-novo proteins

Reciprocally-Coupled Gating: Strange Loops in Bioenergetics, Genetics, and Catalysis

Impedance Matching and the Choice Between Alternative Pathways for the Origin of Genetic Coding

Escapement mechanisms: Efficient free energy transduction by reciprocally‐coupled gating

Collaborators (4)

Peter Wills

George Phillips

Nikolay Dokholyan

Simon Harris

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