Charles Gauthier

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Full Professor

Institut national de la recherche scientifique

Canada

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About

Charles Gauthier is a Full Professor at the Institut national de la recherche scientifique in Canada. His research focuses on carbohydrate chemistry, specifically the synthesis and evaluation of various saponins and their immunological properties. Recent articles include studies on Lewis-X-containing triterpenoid saponins and their effects on HIV-1 infection, as well as the synthesis of rhamnose-modified compounds. He is also involved in the structural characterization of nonionic rhamnolipids and their applications in immunostimulation.

Recent Grants

Grant: Close

Preclinical evaluation of multicomponent glycoconjugate vaccines against melioidosis

Open Date: 2022-04-01

Close Date: 2026-03-31

Grant: Close

Synthèse de saponines chimériques immunostimulantes

Open Date: 2021-04-01

Close Date: 2024-03-31

Grant: Close

New approaches for the stereoselective synthesis of glycans of therapeutic interest

Open Date: 2021-04-01

Close Date: 2022-03-31

Grant: Close

New approaches for the stereoselective synthesis of glycans of therapeutic interest

Open Date: 2020-04-01

Close Date: 2021-03-31

Grant: Close

Synthetic saponins as inhibitors of virus:DC-SIGN interactions

Open Date: 2020-04-01

Close Date: 2021-03-31

Articles (18)

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2025

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2024

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2024

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (11)

Nicole Smalley

University of Washington

UNITED STATES

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Serge Lavoie

Professeur

Université du Québec à Chicoutimi

CANADA

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Adnane Sellam

Université de Montréal

CANADA

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Ajai A. Dandekar

University of Washington

UNITED STATES

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Marie-Christine Groleau

Research Professional/Lab Manager

INRS-Institut Armand-Frappier

CANADA

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Ralph Pantophlet

Associate Professor

Simon Fraser University

CANADA

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Alain Lamarre

Full Professor

Institut national de la recherche scientifique (INRS)

CANADA

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Sandrine Dhondt-Cordelier

Université de Reims Champagne-Ardenne

FRANCE

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Stefanie Ranf

Professor of Plant Science

University of Fribourg

SWITZERLAND

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stephan dorey

Lecturer

Université de Reims Champagne-Ardenne

FRANCE

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Atsushi Kato

Professor and Director

University of Toyama

JAPAN

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Charles Gauthier

Research Interests

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About

Recent Grants

Articles (18)

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

Synthesis of Rhamnose‐Modified Lewis‐X‐Containing Saponins

Structural characterization of a nonionic rhamnolipid from Burkholderia lata

1-Thiosugars: From Synthesis to Applications

Synthesis and cytotoxicity evaluation of d- and l-sugar-containing mono- and bidesmosidic ursane-type saponins

Thioarylation of 6‐Amino‐2,3,6‐trideoxy‐d‐manno‐oct‐2‐ulosonic Acid (IminoKdo): Access to 3,6‐Disubstituted Picolinates and Mechanistic Insights

Synthesis and pharmacological evaluation of nature-inspired phenacyl glycosides

Synthesis of immunostimulatory saponins: A sweet challenge for carbohydrate chemists

C7 Epimerization of Benzylidene-Protected β-d-Idopyranosides Brings Structural Insights into Idose Conformational Flexibility

Evaluation of Azido 3-Deoxy- d - Manno-oct-2-ulosonic Acid (Kdo) Analogues for Click Chemistry-Mediated Metabolic Labeling of Myxococcus xanthus DZ2 Lipopolysaccharide

Total synthesis of the proposed structures of gladiosides I and II

Total Synthesis of a Chimeric Glycolipid Bearing the Partially Acetylated Backbone of Sponge-Derived Agminoside E

Glycosylation and Protecting Group Strategies Towards the Synthesis of Saponins and Bacterial Oligosaccharides: A Personal Account

Progress toward the Development of Glycan-Based Vaccines against Campylobacteriosis

Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids

Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms

Burkholderia thailandensis Methylated Hydroxyalkylquinolines: Biosynthesis and Antimicrobial Activity in Cocultures

Collaborators (11)

Nicole Smalley

Serge Lavoie

Adnane Sellam

Ajai A. Dandekar

Marie-Christine Groleau

Ralph Pantophlet

Alain Lamarre

Sandrine Dhondt-Cordelier

Stefanie Ranf

stephan dorey

Atsushi Kato

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