Chengwen Li

ASSOCIATE PROFESSOR

University of North Carolina at Chapel Hill

United States

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About

Chengwen Li is an Associate Professor at The University of North Carolina at Chapel Hill, United States. His research focuses on gene therapy and the development of innovative adeno-associated virus (AAV) vectors, with recent publications exploring AAV capsids, liver transgene expression, and blood-brain barrier penetration. Professor Li also investigates mucosal vaccination strategies and their effects on immune responses in animal models.

Articles (7)

Year:

2024

Year:

2022

Year:

2022

Year:

2020

Year:

2020

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North Carolina State University

UNITED STATES

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Chengwen Li

Research Interests

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Articles (7)

Rationally engineered novel AAV capsids for intra-articular gene delivery

Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction

Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain

Mucosal Vaccination with UV-Inactivated <i>Chlamydia suis</i> in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ<sup>+</sup> Effector Memory Cells

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity.

Membrane fusion FerA domains enhance adeno-associated virus vector transduction.

Engineering adeno-associated virus vectors for gene therapy.

Collaborators (5)

Taylor Poston

Lizette Lorenz

Catherine O'Connell

Michelle Itano

Tobias Kaeser

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