Chikashi Toyoshima

Professor

University of Tokyo

Japan

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About

Chikashi Toyoshima is a Professor at the University of Tokyo, Japan. His research focuses on the structural and functional dynamics of ion pumps, particularly Na+,K+-ATPase and its interactions with various ligands and states. Recent publications include studies on the mechanisms of cation channel transformation and the structural insights gained from cryo-electron microscopy.

Articles (8)

Year:

2025

Year:

2024

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2023

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2022

Year:

2022

Year:

2021

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Aarhus University

DENMARK

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Chikashi Toyoshima

Research Interests

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Contact this professor

About

Articles (8)

How palytoxin transforms the Na + ,K + pump into a cation channel

The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase.

Crystal structures of Na+,K+‐ATPase reveal the mechanism that converts the K+‐bound form to Na+‐bound form and opens and closes the cytoplasmic gate

Cryo‐electron microscopy of Na+,K+‐ATPase reveals how the extracellular gate locks in the E2·2K+ state

Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids

The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes

Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state

What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2

Collaborators (6)

Ryuta Kanai

Haruo Ogawa

Masahide Kikkawa

Atsushi Nakagawa

Shigekazu Nagata

Bente Vilsen

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