Christina Bourne

Associate Professor

University of Oklahoma

United States

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About

Dr. Christina Bourne is an Associate Professor at the University of Oklahoma, USA. Her research focuses on bacterial toxins, DNA gyrase inhibition, and antibiotic resistance mechanisms. Recent articles reflect her work on the molecular interactions of TA systems and their implications for developing antibacterial strategies.

Articles (9)

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2025

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2024

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2024

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2022

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2022

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2022

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2020

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2020

Year:

2020

Collaborators (2)

Shanteri Singh

Assistant Professor

University of Oklahoma

UNITED STATES

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Matthew C. O'Reilly

Villanova University

UNITED STATES

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Christina Bourne

Research Interests

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Articles (9)

Broken beyond repair: TA system ParE toxins mediate effective gyrase inhibition without driving resistance

Escherichia coli cells evade inducible parE toxin expression by reducing plasmid copy number

Friend or Foe: Protein Inhibitors of DNA Gyrase

Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure–Activity Relationships and Mechanism of Action

Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus

ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems

Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins

Collaborators (2)

Shanteri Singh

Matthew C. O'Reilly

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