Christoph Handschin

Professor

Universität Basel Department Biozentrum

Switzerland

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About

Christoph Handschin is a Professor at the Universität Basel Department Biozentrum in Switzerland. His research focuses on exercise physiology, metabolic regulation, and the molecular mechanisms underlying skeletal muscle function and adaptation to training. Recent articles authored by him explore topics such as biomarkers of aging, the effects of endurance training on chromatin structure, and the intricate relationship between metabolic dysregulation and muscle disorders.

Articles (23)

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2025

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2022

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2022

Collaborators (7)

Mihaela Zavolan

Professor

University of Basel

SWITZERLAND

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Michael Sinnreich

Clinical Professor

University Hospital Basel

SWITZERLAND

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Dominik Burri

University of Basel

SWITZERLAND

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Markus A Rüegg

University of Basel

SWITZERLAND

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Alexander Schmidt

University of Basel

SWITZERLAND

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Aurel Leuchtmann

Universität Basel Department Biozentrum

SWITZERLAND

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Stephan Krähenbühl

University Hospital Basel

SWITZERLAND

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Christoph Handschin

Research Interests

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Articles (23)

Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response.

Biomarkers of aging: from molecules and surrogates to physiology and function

Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle

Metabolic dysregulation contributes to the development of dysferlinopathy

Mitochondrial Maintenance in Skeletal Muscle

Biomarkers of aging: functional aspects still trump molecular parameters

Unlocking athletic potential: Exploring exercise physiology from mechanisms to performance.

Robust, Precise, and Deep Proteome Profiling Using a Small Mass Range and Narrow Window Data-Independent-Acquisition Scheme

Molecular aspects of the exercise response and training adaptation in skeletal muscle

More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα.

More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα

Molecular control of endurance training adaptation in male mouse skeletal muscle

Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α

Drugs, clocks and exercise in ageing: hype and hope, fact and fiction

Effects of high‐resistance wheel running on hallmarks of endurance and resistance training adaptations in mice

The molecular athlete: exercise physiology from mechanisms to medals.

Complex regulatory processes control exercise adaptations of skeletal muscle

Churchill was wrong – do sports!

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.

PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds

PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle

Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity.

Interleukin‐6 potentiates endurance training adaptation and improves functional capacity in old mice

Collaborators (7)

Mihaela Zavolan

Michael Sinnreich

Dominik Burri

Markus A Rüegg

Alexander Schmidt

Aurel Leuchtmann

Stephan Krähenbühl

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