Chunyi Hu

Assistant Professor

National University of Singapore (NUS)

Singapore

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About

Chunyi Hu is an Assistant Professor at the National University of Singapore. His research primarily focuses on the molecular engineering and functional characterization of CRISPR-Cas systems, including both type I and type III systems, as well as their applications in genome editing and antiviral signaling. Recent publications highlight his investigations into the structural dynamics and novel functionalities of CRISPR components, contributing significantly to the advancement of this field.

Articles (17)

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2025

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2025

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2025

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2024

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2024

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2024

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2024

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2024

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

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2020

Collaborators (5)

Henning Stahlberg

Professor ad personam

University of Lausanne

SWITZERLAND

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Ki Hyun Nam

SOUTH KOREA

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Ailong Ke

Professor

Cornell University

UNITED STATES

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SONALI MAJUMDAR

Assistant Dean for Professional Development

Princeton University

UNITED STATES

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Jochem Vink

Victoria University of Wellington

NEW ZEALAND

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Chunyi Hu

Research Interests

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Articles (17)

Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM

Cas7 meets Cas14: a strategic partnership in the type VII CRISPR-Cas

Redefining DNA cleavage in type I CRISPR systems with the HNH domain

Antiviral signaling of a type III CRISPR-associated deaminase

Dual role of phage terminase in Salmonella enterica oxidative stress response

Efficient, compact, and versatile: Type I‐F2 CRISPR‐Cas system

The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B

Structure and genome editing of type I-B CRISPR-Cas

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9

Craspase is a CRISPR RNA-guided, RNA-activated protease

Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas

Erratum: Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast (Nucleic Acids Res (2019) 47:3 (1573-1584) DOI: 10.1093/nar/gky1186)

Real-time observation of CRISPR spacer acquisition by Cas1–Cas2 integrase

Identification of a novel melatonin-binding nuclear receptor: Vitamin D receptor

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Collaborators (5)

Henning Stahlberg

Ki Hyun Nam

Ailong Ke

SONALI MAJUMDAR

Jochem Vink

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