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Clare Isacke

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Professor of Molecular Cell Biology

Institute of Cancer Research

United Kingdom

Research Interests

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Recent Grants

Grant: Close

Collagen remodelling by stromal fibroblasts in breast cancer metastasis

Open Date: 2015-06-01

Close Date: 2018-05-31

Grant: Close

Tumour-stroma interactions in metastatic breast cancer

Open Date: 2012-08-01

Close Date: 2019-07-01

Grant: Close

Molecular Biology Team - Tumour-Stroma Interactions in Breast Cancer

Open Date: 2011-08-01

Close Date: 2012-07-31

Grant: Close

Identification and characterisation of novel therapeutic targets in breast cancer metastasis

Open Date: 2010-10-04

Close Date: 2013-10-03

Grant: Close

Functional crosstalk between ER and RET - implications for endocrine therapy response

Open Date: 2009-10-01

Close Date: 2013-01-31

Articles (12)

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2026

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2025

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2024

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2023

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2023

Collaborators (18)

Angela Riedel

Junior Group Leader

University of Würzburg

GERMANY

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Christopher Lord

Professor of Cancer Genomics

Institute of Cancer Research

UNITED KINGDOM

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Ariella Hanker

Associate Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Maximilian Reichert

GERMANY

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Jeroen Bugter

University of Maastricht

NETHERLANDS

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Rania EL BOTTY

Institut Curie

FRANCE

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Pier Luigi Lollini

Professor

University of Bologna

ITALY

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Christine Klement

Technical University of Munich

GERMANY

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Sven Rottenberg

Director

University of Bern

SWITZERLAND

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Andrew Tutt

Professor of Clinical Oncology

Institute of Cancer Research

UNITED KINGDOM

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Giovanna Ambrosini

Senior Scientist

EPFL (École Polytechnique Fédérale de Lausanne)

SWITZERLAND

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Marcos Malumbres

Director

Vall d'Hebron Institute of Oncology

SPAIN

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Amanda Fitzpatrick

Clinical Senior Lecturer

King's College London

UNITED KINGDOM

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Andrea Morandi

University of Florence

ITALY

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Frances Turrell

The University of Manchester

UNITED KINGDOM

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Elinor Sawyer

King’s College London

UNITED KINGDOM

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Caroline Malhaire

Institut Curie

FRANCE

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ludivine morisset

Institut Curie

FRANCE

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Clare Isacke

Research Interests

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Recent Grants

Articles (12)

A disease model resource reveals core principles of tissue-specific cancer evolution

LOX Inhibition Disrupts a Collagen–Integrin–MYC Axis to Suppress Progression of Invasive Lobular Carcinoma

Clinical challenges and proposed solutions for patients with invasive lobular breast cancer

Targeting Transcriptional Regulation with a CDK9 Inhibitor Suppresses Growth of Endocrine- and Palbociclib-Resistant ER+ Breast Cancers

International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations

Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer

Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis

Therapy-induced normal tissue damage promotes breast cancer metastasis.

Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy: A systematic review and meta-analysis

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype

Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma.

Collaborators (18)

Angela Riedel

Christopher Lord

Ariella Hanker

Maximilian Reichert

Jeroen Bugter

Rania EL BOTTY

Pier Luigi Lollini

Christine Klement

Sven Rottenberg

Andrew Tutt

Giovanna Ambrosini

Marcos Malumbres

Amanda Fitzpatrick

Andrea Morandi

Frances Turrell

Elinor Sawyer

Caroline Malhaire

ludivine morisset

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