Claus Loland

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Professor in Neurophysiology

University of Copenhagen

Denmark

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About

Claus Loland is a Professor in Neurophysiology at the University of Copenhagen, Denmark. His research focuses on the structure and function of neurotransmitter transporters, particularly the dopamine and serotonin transporters. Recent articles discuss topics such as the binding interactions of cocaine, innovative approaches to enhance membrane protein stability, and the exploration of high-affinity inhibitors targeting atypical dopamine transporters.

Recent Grants

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Does K+ play a generic role in the substrate transport process of Na+-coupled neurotransmitter transporters?

Open Date: 2020-01-01

Close Date: 2021-12-01

Grant: Close

Elucidating the role of potassium in the molecular function of transport proteins

Open Date: 2017-07-01

Close Date: 2020-06-01

Grant: Close

Direct assessment of translocation dynamics and drug binding conformations in the dopamine transporter

Open Date: 2016-01-01

Close Date: 2018-12-01

Articles (20)

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2021

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2021

Collaborators (12)

Katarzyna Targowska-Duda

Associate Professor

Medical University of Lublin

POLAND

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Mikael Bols

Københavns Universitet

DENMARK

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Allison Heskes

Assistant Professor

University of Copenhagen

DENMARK

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Kasper Rand

Københavns Universitet

DENMARK

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Jonas Sigurd Mortensen

Assistant Professor

University of Copenhagen

DENMARK

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Susan Semple

University of South Australia

AUSTRALIA

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Ulrik Gether

Københavns Universitet

DENMARK

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Bernadette Byrne

UNITED KINGDOM

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Ashwani Kumar

Research Professor

Hanyang University - Ansan Campus

SOUTH KOREA

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Muhammad Ehsan

Hanyang University

SOUTH KOREA

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Louise Laursen

Aarhus University

DENMARK

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Anders Skov Kristensen

Associate professor

University of Copenhagen

DENMARK

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Claus Loland

Research Interests

Contact this professor

About

Recent Grants

Articles (20)

Is Cocaine Protonated When it Binds to the Dopamine Transporter?

Author Correction: Structure of the human dopamine transporter in complex with cocaine

Structure of the human dopamine transporter in complex with cocaine

Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

Fluorescent non-canonical amino acid provides insight into the human serotonin transporter

Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance

Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study

The dopamine transporter antiports potassium to increase the uptake of dopamine

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

Probing the Impact of Temperature and Substrates on the Conformational Dynamics of the Neurotransmitter:Sodium symporter LeuT: Impact on LeuT of temperature and Ala/Leu binding

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability

Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

Collaborators (12)

Katarzyna Targowska-Duda

Mikael Bols

Allison Heskes

Kasper Rand

Jonas Sigurd Mortensen

Susan Semple

Ulrik Gether

Bernadette Byrne

Ashwani Kumar

Muhammad Ehsan

Louise Laursen

Anders Skov Kristensen

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