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Clinton Jones

Sitlington Professor of Infectious Diseases

Oklahoma State University

United States

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Research Interests

Immunology

20%

Cell Biology

40%

Inflammatory Biology

50%

Stress Biology

40%

Receptor Biology

40%

Hormone Biology

30%

Neuroinflammation

30%

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Recent Grants

Grant: Close

Regulation of latency-reactivation cycle by ORF2 and beta-catenin/Wnt signaling pathway.

Open Date: 2018-07-01

Close Date: 2021-06-01

Grant: Close

Regulation of beta-catenin in neurons during the HSV-1 latency-reactivation cycle.

Open Date: 2018-01-01

Close Date: 2020-12-01

Grant: Close

Analysis of Bovine Herpesvirus 1 Stress Induced Reactivation from Latency.

Open Date: 2014-08-01

Close Date: 2018-09-01

Articles19

Glucocorticoid receptor occupancy of key bovine alphaherpesvirus 1 (BoHV-1) promoters correlates with chromatin remodeling during reactivation from latency

Article Link

Year:

2025

Human alpha-herpesvirus 1 (HSV-1) viral replication and reactivation from latency are expedited by the glucocorticoid receptor

Article Link

Year:

2025

Murine nasal-associated lymphoid tissue (NALT) harbors human alphaherpesvirus 1 (HSV-1) DNA during latency, and dexamethasone triggers viral replication

Article Link

Year:

2025

Examination of neuro-inflammation and senescence in brainstem of aged mice latently infected with human alphaherpesvirus 1 (HSV-1)

Article Link

Year:

2024

Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3, but not the antibiotic Mithramycin A, stimulates human alphaherpesvirus 1 (HSV-1) replication

Article Link

Year:

2024

Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3 transactivate HSV-1 ICP0 promoter sequences but a GC-rich binding antibiotic, Mithramycin A, impairs reactivation from latency

Article Link

Year:

2024

A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter

Article Link

Year:

2024

Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter

Article Link

Year:

2024

Intimate Relationship Between Stress and Human Alpha-Herpes Virus 1 (HSV-1) Reactivation from Latency

Article Link

Year:

2023

Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis -Regulatory Module within the VP16 Promoter

Article Link

Year:

2023

Impaired glucocorticoid receptor function attenuates herpes simplex virus 1 production during explant-induced reactivation from latency in female mice

Article Link

Year:

2023

Stress Triggers Expression of Bovine Herpesvirus 1 Infected Cell Protein 4 (bICP4) RNA during Early Stages of Reactivation from Latency in Pharyngeal Tonsil

Article Link

Year:

2022

Herpes Simplex Virus Type 1 Preferentially Enhances Neuro-Inflammation and Senescence in Brainstem of Female Mice

Article Link

Year:

2022

Regulation of herpes simplex virus type 1 latency-reactivation cycle and ocular disease by cellular signaling pathways

Article Link

Year:

2022

Progesterone Sporadically Induces Reactivation from Latency in Female Calves but Proficiently Stimulates Bovine Herpesvirus 1 Productive Infection

Article Link

Year:

2022

A Pioneer Transcription Factor and Type I Nuclear Hormone Receptors Synergistically Activate the Bovine Herpesvirus 1 Infected Cell Protein 0 (ICP0) Early Promoter

Article Link

Year:

2021

Transactivation of Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 4 Enhancer by Glucocorticoid Receptor and Stress-Induced Transcription Factors Requires Overlapping Krüppel-Like Transcription Factor 4/Sp1 Binding Sites

Article Link

Year:

2021

Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency

Article Link

Year:

2020

Herpes simplex virus 1 regulates β-catenin expression in TG neurons during the latency-reactivation cycle

Article Link

Year:

2020

Collaborators6

Peter Hoyt

Oklahoma State University

UNITED STATES

Madhan Subramanian

Oklahoma State University

UNITED STATES

Fouad Elmayet

Research Assistant Professor

Oklahoma State University

UNITED STATES

Jeffery Ostler

Oklahoma State University

UNITED STATES

Kelly Harrison

Assistant Professor

Oklahoma State University

UNITED STATES

Vanessa Claire Santos

Graduate Teaching Assistant

Oklahoma State University

UNITED STATES

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