Coleen Murphy

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Princeton University

United States

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Professor Coleen Murphy is a faculty member at Princeton University in the United States. Her research focuses on cognitive decline and behavior in C. elegans, exploring topics such as transgenerational epigenetic inheritance, neuronal transcriptomics, and the molecular mechanisms underlying aging. Recent articles by Professor Murphy investigate the influence of insulin signaling and pathogen interactions on behavioral regulation and cognitive aging in model organisms.

Recent Grants

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Systems Modeling of Alzheimers Disease in C. elegans

Open Date: 2017-09-15

Close Date: 2022-06-30

Grant: Close

Toward the Tissue-ome: A Map of the C. elegans Cell-specific Transcriptome

Open Date: 2015-09-30

Close Date: 2020-07-31

Grant: Close

Dissecting the genetic and molecular networks underlying longevity and aging

Open Date: 2015-09-30

Close Date: 2018-08-31

Grant: Close

Molecular Mechanisms Regulating Age-Related Cognitive Decline

Open Date: 2009-08-01

Close Date: 2020-05-31

Grant: Close

Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators

Open Date: 2008-09-30

Close Date: 2013-08-31

Articles (20)

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2021

Collaborators (3)

Danielle Mor

Augusta University

UNITED STATES

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Yujin Lee

Samsung (South Korea)

SOUTH KOREA

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Seokjin Ham

Research Assistant Professor

Korea Advanced Institute of Science and Technology

SOUTH KOREA

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Coleen Murphy

Research Interests

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Recent Grants

Articles (20)

C. elegans cognitive decline with age: more than just wiggling forward and backward

Single-nucleus neuronal transcriptional profiling of male C. elegans uncovers regulators of sex-specific and sex-shared behaviors

Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance

Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance

C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1

Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning

Pseudomonas aeruginosa modulates both Caenorhabditis elegans attraction and pathogenesis by regulating nitrogen assimilation

The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

Male-specific behavioral and transcriptomic changes in aging C. elegans neurons

Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

Aging research: A field grows up

piRNAs regulate a Hedgehog germline-to-soma pro-aging signal

CeLab, a microfluidic platform for the study of life history traits, reveals metformin and SGK-1 regulation of longevity and reproductive span

Oocyte mitophagy is critical for extended reproductive longevity

Males induce premature demise of the opposite sex by multifaceted strategies

Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant

High-throughput behavioral screen in C. elegans reveals Parkinson's disease drug candidates

Reduced insulin/igf1 signaling prevents immune aging via zip-10/bzip–mediated feedforward loop

The role of the Cer1 transposon in horizontal transfer of transgenerational memory

Collaborators (3)

Danielle Mor

Yujin Lee

Seokjin Ham

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