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Colin Willoughby

Professor of Ophthalmology

University of Ulster

United Kingdom

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Research Interests

Cell Biology

80%

Medical Imaging

20%

Ophthalmology

40%

Retinal Disease

40%

Ocular Physiology

40%

Microrna Research

40%

Epithelial-mesenchymal Transition

30%

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Recent Grants

Grant: Close

Pharmacogenetics of Steroid-Induced Glaucoma

Open Date: 2018-10-01

Close Date: 2021-09-30

Grant: Close

GlaucoMirs: MicroRNA based therapeutics to treat ocular fibrosis in glaucoma

Open Date: 2018-08-01

Close Date: 2021-07-31

Grant: Close

Genetics of Advanced Glaucoma: Towards Predicting and Preventing Blindness

Open Date: 2018-01-01

Close Date: 2019-12-31

Grant: Close

Unravelling the molecular mechanism of connective tissue growth factor (CCN2) in glaucoma.

Open Date: 2016-09-01

Close Date: 2019-08-31

Grant: Close

Novel Chemical Crosslinking of the Cornea for Treatment of Keratoconus

Open Date: 2016-01-01

Close Date: 2018-07-30

Articles22

Hsa-MiR-483 -3p regulates the extracellular matrix proteins via TGFβ2/SMAD4 signaling in the glucocorticoid-responsive human trabecular meshwork cells

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Year:

2025

COVID-19 infection and intense physical activity in hypokalemic periodic paralysis

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Year:

2025

Transcriptome Profiling of Trabecular Meshwork Progenitor Cells

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Year:

2025

Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma

Article Link

Year:

2025

Main genetic entities associated with tooth agenesis

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Year:

2025

Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management

Article Link

Year:

2024

The TGFβ Induced MicroRNAome of the Trabecular Meshwork

Article Link

Year:

2024

The Suppression of the Epithelial to Mesenchymal Transition in Prostate Cancer through the Targeting of MYO6 Using MiR-145-5p

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Year:

2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Article Link

Year:

2024

Glucagon-like Peptide 1 Receptor Agonist use and the effect on diabetic retinopathy: An uncertain relationship

Article Link

Year:

2024

Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue

Article Link

Year:

2024

Targeting of AKT1 by miR-143-3p Suppresses Epithelial-to-Mesenchymal Transition in Prostate Cancer

Article Link

Year:

2023

Novel EDA mutations cause X-linked hypohidrotic ectodermal dysplasia: the first study from Venezuela

Article Link

Year:

2023

Challenges in Communicating a Genetic Diagnosis

Article Link

Year:

2023

Automatic detection of glaucoma via fundus imaging and artificial intelligence: A review

Article Link

Year:

2023

Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients

Article Link

Year:

2023

Small RNA Sequencing Reveals a Distinct MicroRNA Signature between Glucocorticoid Responder and Glucocorticoid Non-Responder Primary Human Trabecular Meshwork Cells after Dexamethasone Treatment

Article Link

Year:

2023

Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation Glaucoma

Article Link

Year:

2022

Extended Overview of Ocular Phenotype with Recent Advances in Hypohidrotic Ectodermal Dysplasia

Article Link

Year:

2022

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

Article Link

Year:

2022

MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility

Article Link

Year:

2022

Evidence of impaired mitochondrial cellular bioenergetics in ocular fibroblasts derived from glaucoma patients

Article Link

Year:

2022

Collaborators14

David Criddle

Senior Lecturer

University of Liverpool

UNITED KINGDOM

Krishnakumar Kizhatil

Assistant Professor

Ohio State University

UNITED STATES

Silvester Czanner

Professor of Computer Science and Head of the School of Computer and Engineering Sciences

University of Chester

UNITED KINGDOM

Kevin J. Hamill

University of Liverpool

UNITED KINGDOM

Markus Kuehn

Professor

Iowa State University

UNITED STATES

Antonino Morabito

Professor of Surgery

University of Florence

ITALY

Rudolf Fuchshofer

University of Regensburg

GERMANY

David Simpson

Professor

The Queen's University Belfast

UNITED KINGDOM

Francesco SEMERARO

Full Professor

University of Brescia

ITALY

Ala Al Kafri

Teesside University

UNITED KINGDOM

George Bou-Gharios

Professor of Matrix Biology

University of Liverpool

UNITED KINGDOM

Declan McKenna

Lecturer

University of Ulster

UNITED KINGDOM

Sarah Atkinson

Lecturer in Stratified Medicine

University of Ulster

UNITED KINGDOM

Carl Sheridan

University of Liverpool

UNITED KINGDOM

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