Daan van Aalten

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Professor

Aarhus University

Denmark

Research Interests

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Professor Daan van Aalten is a faculty member at Aarhus University in Denmark. His research focuses on O-GlcNAc transferase and its implications in intellectual disabilities, including studies on neurodevelopmental defects and proteostatic control. Additionally, he explores therapeutic targets in invasive aspergillosis and bacterial biofilm formation. His recent publications reflect a commitment to understanding the molecular mechanisms underlying these significant biological challenges.

Recent Grants

Grant: Close

Genetic and chemical validation of sugar nucleotide biosynthesis as a target against Candida albicans

Open Date: 2017-03-01

Close Date: 2022-02-01

Grant: Close

Mechanisms of O-GlcNAc signalling

Open Date: 2016-03-01

Close Date: 2021-02-01

Grant: Close

High throughput bio-layer interferometry at Dundee for anti-microbial and interaction studies.

Open Date: 2015-01-22

Close Date: 2016-01-21

Grant: Close

Genetic, structural and chemical validation of Aspergillus fumigatus cell wall targets

Open Date: 2014-11-01

Close Date: 2019-10-31

Grant: Close

Molecular mechanisms of O-GlcNAc signalling.

Open Date: 2014-06-01

Close Date: 2016-02-29

Articles (16)

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2025

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2025

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (5)

Natalie Bamford

University of Dundee

UNITED KINGDOM

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Lance Wells

University of Georgia

UNITED STATES

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Cait MacPhee

Reader

University of Edinburgh

UNITED KINGDOM

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Laura Hobley

Assistant Professor

University of Nottingham

UNITED KINGDOM

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Annette Schenck

full Prof.

Radboud University Medical Center

NETHERLANDS

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Daan van Aalten

Research Interests

Contact this professor

About

Recent Grants

Articles (16)

Zscan4 as a candidate conveyor of early developmental defects in O-GlcNAc transferase intellectual disability

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

Lateral interactions govern self-assembly of the bacterial biofilm matrix protein BslA

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability

Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis

Genetic and structural validation of phosphomannomutase as a cell wall target in Aspergillus fumigatus

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1

Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

A mouse model for functional dissection of TAB1 O-GlcNAcylation

O-GlcNAcase contributes to cognitive function in Drosophila

Targeting a critical step in fungal hexosamine biosynthesis

An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase

Collaborators (5)

Natalie Bamford

Lance Wells

Cait MacPhee

Laura Hobley

Annette Schenck

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