Daniel Nettersheim

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Univ.-Professor

Heinrich Heine University Düsseldorf

Germany

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Daniel Nettersheim is a Univ.-Professor at Heinrich-Heine-Universität Düsseldorf, Germany. His research focuses on testicular germ cell tumors, rare diseases, and the molecular mechanisms driving tumorigenesis. Recent articles highlight his work on the pathogenesis, diagnosis, and treatment resistance of germ cell tumors, as well as investigations into (epi)genetic features and novel therapeutic approaches.

Recent Grants

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Research project funding

Open Date: 2023-02-01

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Research project funding

Open Date: 2022-02-01

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Research project funding

Open Date: 2020-10-01

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Maximilian Nitze award

Open Date: 2020-09-01

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Research project funding

Open Date: 2020-08-01

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Daniel Nettersheim

Research Interests

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Recent Grants

Articles (20)

[New insights from basic research on testicular germ cell tumors and updated tumorigenesis].

[Challenges in the research and diagnosis of rare diseases].

Induction of SOX17 with stimulation of WNT, TGF-beta, and FGF signaling drives embryonal carcinomas into the yolk-sac tumor lineage resulting in increased cisplatin resistance.

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2.

The New Tumour Biomarker miRNA‐371‐3p Influences Cisplatin Sensitivity of Testicular Germ Cell Tumour Cell Lines

Pathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnostics

(Epi)genetic and Genomic Features of Pediatric and Adult Germ Cell Tumors.

[Histopathological analysis of germ cell tumours: aspects to consider].

Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages.

Characterization of the dehydrogenase-reductase DHRS2 and its involvement in histone deacetylase inhibition in urological malignancies.

CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners.

Updating germ cell tumour pathogenesis - the ability of seminomas for FOXA2-driven extra-embryonic differentiation.

Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours.

Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options.

Establishment and evaluation of a dual HDAC / BET inhibitor as a therapeutic option for germ cell tumors and other urological malignancies.

[Current view on testicular tumors from a developmental biological perspective : Important biomarkers and molecular pathological investigations].

Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level.

Special Issue on Testis Cancer.

Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry.

Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights.

Collaborators (6)

Stefan Küffer

Björn Stork

Philipp Ströbel

Karina Stephanie Krings

Axel Schambach

christoph peter

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