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David-Alexandre Trégouët

Has grant

Team Director / 1st Class INSERM Research Director

INSERM U1219

France

Research Interests

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Professors in France Professors in Biostatistics Biostatistics professors in France

Recent Grants

Grant: Open

ENDOMORF: Characterization of non-coding Endoglin mutations leading to pathogenic upstream Open Reading Frames in Hereditary Hemorrhagic Telangiectasia – promises for novel therapeutic strategies

Open Date: 2024-01-01

Close Date: 2027-06-01

Grant: Open

MORPHEUS – Prognosis improvement of unprovoked venous thromboembolism using personalized anticoagulant therapy

Open Date: 2024-01-01

Close Date: 2028-12-01

Grant: Open

TWIST: Biological signature of bleeding burden in von Willebrand disease: towards new targets for diagnosis and treatment

Open Date: 2023-04-01

Close Date: 2027-03-01

Grant: Open

GICICA: GenetIC determInants of myoCArditis induced by immune-checkpoint inhibitors

Open Date: 2023-01-01

Close Date: 2027-11-01

Grant: Close

PROGRESS: PRecisiOn medicine in CAD patients: artificial intelliGence for integRated gEnomic, functional and anatomical aSSessment of the coronary collateral circulation

Open Date: 2021-01-01

Close Date: 2024-12-01

Articles (20)

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Collaborators (18)

Panos Sergouniotis

Senior Lecturer & Honorary Consultant

The University of Manchester

UNITED KINGDOM

David-Alexandre Trégouët

Research Interests

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Recent Grants

Articles (20)

Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries

Genomics of Long-Term Complications of Childhood Leukemia: Rationale and Design of the GenLEA Study.

A multiomics approach reveals novel regulators of plasma factor V levels, highlighting CLEC4M as a clearance receptor.

Histo-blood group ABO system transferase plasma levels and risk of future venous thromboembolism: the HUNT study.

Population-specific ABO haplotypes reveal distinct venous thromboembolism risk in East Asians: insights from a large-scale genetic study.

Updated LIfestyle for BRAin health (LIBRA2) Score, Genetics, and Risk of Alzheimer Disease, Vascular Dementia, and Stroke in Older Adults

A smoothing method for DNA methylome analysis to enhance epigenomic signature detection in epigenome-wide association studies.

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.

Targeting a Pathogenic Variant Creating an Upstream AUG in the &lt;i&gt;ENG&lt;/i&gt; 5' Untranslated Region with Antisense Oligonucleotides Fails to Restore Protein Expression.

Molecular determinants of thrombosis recurrence risk across venous thromboembolism subtypes.

From paleness to albinism: Contribution of OCA2 exon 10 skipping to hypopigmentation

Overlapping upstream ORFs ending at c.125 lead to reduced Endoglin, contributing to Hereditary Hemorrhagic Telangiectasia

Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.

Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.

Sex-specific DNA methylation marks associated with sex-biased risk of recurrence in unprovoked venous thromboembolism.

Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5′UTRs

Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies.

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening.

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Collaborators (18)

Panos Sergouniotis

Catherine Helmer

Valeria Lo Faro

Roddy Walsh

Weihua Guan

Christian Jonasson

A.s Amin

Daniel J. Rigden

Ming-Huei Chen

Philip Dusart

Alexander Doney

Ify Mordi

Sebastian Köhler

Sundararajan Srinivasan

John-Bjarne Hansen

Doug Speed

Jordan A. Shavit

Chloe James

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Targeting a Pathogenic Variant Creating an Upstream AUG in the <i>ENG</i> 5' Untranslated Region with Antisense Oligonucleotides Fails to Restore Protein Expression.