David Brockwell

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University of Leeds

United Kingdom

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David Brockwell is a Professor at the University of Leeds in the United Kingdom. His research focuses on the thermodynamic and structural analysis of amyloid formation, fluid dynamics in protein assembly, and the biophysical characterization of therapeutic antibodies. Recent articles highlight his work on deep mutational scanning, protein networks, and the visualization of self-assembly processes in biophysical systems.

Recent Grants

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Exploiting Engineered Polyproteins in the Modular Design of Robust, Tuneable and Biofunctional Hydrogels

Open Date: 2018-03-01

Close Date: 2024-01-31

Grant: Close

Leeds integrated atomic force and confocal microscopy for life science applications

Open Date: 2017-08-14

Close Date: 2018-08-13

Grant: Close

Unravelling BamA Function Using Fluorescence & Single Molecule Force Experiments

Open Date: 2016-09-30

Close Date: 2019-09-29

Grant: Close

In vivo selection of bioprocessable biopharmaceuticals

Open Date: 2015-05-31

Close Date: 2016-05-30

Grant: Close

Probing biomolecular interactions by combining ETD-tandem mass spectrometry with chemical footprinting methodologies.

Open Date: 2015-01-01

Close Date: 2015-12-31

Articles (20)

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2020

Collaborators (13)

Antreas C. Kalli

University of Leeds

UNITED KINGDOM

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Sheena E Radford

Astbury Professor of Biophysics

University of Leeds

UNITED KINGDOM

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Jeanine Williams

University of Leeds

UNITED KINGDOM

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Anastasia Zhuravleva

Lecturer

University of Leeds

UNITED KINGDOM

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Stephen Evans

Professor of Physics

University of Leeds

UNITED KINGDOM

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Bogdan I. Iorga

Université Paris-Saclay

FRANCE

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Anders Aufderhorst-Roberts

Lecturer in Soft Condensed Matter Physics

University of Durham

UNITED KINGDOM

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Arwen Tyler

Imperial College London

UNITED KINGDOM

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Tímea Feller

University of Leeds

UNITED KINGDOM

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Emanuele Paci

University of Bologna

ITALY

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Antonio N. Calabrese

University of Leeds

UNITED KINGDOM

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Sally Peyman

Associate Professor

University of Leeds

UNITED KINGDOM

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Lorna Dougan

Associate Professor

University of Leeds

UNITED KINGDOM

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David Brockwell

Research Interests

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About

Recent Grants

Articles (20)

Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation

Structural and thermodynamic classification of amyloid polymorphs

In the flow, how fluid dynamics shapes amyloid formation

Nanomachine Networks: Functional All-Enzyme Hydrogels from Photochemical Cross-Linking of Glucose Oxidase

Competition between cross-linking and force-induced local conformational changes determines the structure and mechanics of labile protein networks

Capturing the impact of protein unfolding on the dynamic assembly of protein networks

Exploring a Role for Flow-Induced Aggregation Assays in Platform Formulation Optimisation for Antibody-Based Proteins

Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline

Dual client binding sites in the ATP-independent chaperone SurA

Structural and mechanical properties of folded protein hydrogels with embedded microbubbles

Diversity of viscoelastic properties of an engineered muscle-inspired protein hydrogel

Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks

Collagen-like Motifs of SasG: A Novel Fold for Protein Mechanical Strength

Visualization of Self-Assembly and Hydration of a β-Hairpin through Integrated Small and Wide-Angle Neutron Scattering

Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding

The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis

Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs

PyXlinkViewer: A flexible tool for visualization of protein chemical crosslinking data within the PyMOL molecular graphics system

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

Using protein engineering to understand and modulate aggregation

Collaborators (13)

Antreas C. Kalli

Sheena E Radford

Jeanine Williams

Anastasia Zhuravleva

Stephen Evans

Bogdan I. Iorga

Anders Aufderhorst-Roberts

Arwen Tyler

Tímea Feller

Emanuele Paci

Antonio N. Calabrese

Sally Peyman

Lorna Dougan

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