David Chalupa

University of Rochester Medical Center

United States

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Articles (14)

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Interleukin-17A (IL-17A) neutralization has shown benefit previously in preclinical models of transplant-associated bronchiolitis obliterans (BO), yet it remains unknown whether IL-17A neutralization has similar benefit for other forms of BO. Here, IL-17A neutralization fails to prevent severe airway remodeling in rats exposed repetitively to the flavoring chemical diacetyl, and instead, promotes a proinflammatory microenvironment with increased expression of TNF-α, IL-1β, and NF-κB within the lung.

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Year:

2020

Collaborators (4)

Marissa Sobolewski

Assistant Professor

University of Rochester Medical Center

UNITED STATES

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Mauro Masiol

Associate Professor

Università Ca' Foscari

ITALY

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David Rich

Associate Professor of Public Health Sciences, Medicine, and Environmental Medicine; Director of Epidemiology PhD and MS Programs; Director of Epidemiology Research, Department of Public Health Sciences

University of Rochester Medical Center

UNITED STATES

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Matthew D. McGraw

University of Rochester Medical Center

UNITED STATES

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David Chalupa

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Articles (14)

Developmental Ambient Air Pollution Exposure in Mice Alters Fronto-Striatal Neurotransmitter System Function: Male-Biased Serotonergic Vulnerability

Long term trends in source apportioned particle number concentrations in Rochester NY

Male-biased vulnerability of mouse brain tryptophan/kynurenine and glutamate systems to adolescent exposures to concentrated ambient ultrafine particle air pollution

The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice

Triggering of ST-elevation myocardial infarction by ultrafine particles in New York: Changes following Tier 3 vehicle introduction

IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats

Long-term trends of ultrafine and fine particle number concentrations in New York State: Apportioning between emissions and dispersion

The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice

Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Correction to: Term birth weight and ambient air pollutant concentrations during pregnancy, among women living in Monroe County, New York (Journal of Exposure Science & Environmental Epidemiology, (2019), 29, 4, (500-509), 10.1038/s41370-019-0131-8)

Protein thiol oxidation in the rat lung following e-cigarette exposure

Wintertime Wood Smoke, Traffic Particle Pollution, and Preeclampsia

Collaborators (4)

Marissa Sobolewski

Mauro Masiol

David Rich

Matthew D. McGraw

Make your next move.

David Chalupa

Research Interests

Explore related searches

Contact this professor

Articles (14)

Developmental Ambient Air Pollution Exposure in Mice Alters Fronto-Striatal Neurotransmitter System Function: Male-Biased Serotonergic Vulnerability

Long term trends in source apportioned particle number concentrations in Rochester NY

Male-biased vulnerability of mouse brain tryptophan/kynurenine and glutamate systems to adolescent exposures to concentrated ambient ultrafine particle air pollution

The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice

Triggering of ST-elevation myocardial infarction by ultrafine particles in New York: Changes following Tier 3 vehicle introduction

IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats

Long-term trends of ultrafine and fine particle number concentrations in New York State: Apportioning between emissions and dispersion

The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice

Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Correction to: Term birth weight and ambient air pollutant concentrations during pregnancy, among women living in Monroe County, New York (Journal of Exposure Science &amp; Environmental Epidemiology, (2019), 29, 4, (500-509), 10.1038/s41370-019-0131-8)

Protein thiol oxidation in the rat lung following e-cigarette exposure

Wintertime Wood Smoke, Traffic Particle Pollution, and Preeclampsia

Collaborators (4)

Marissa Sobolewski

Mauro Masiol

David Rich

Matthew D. McGraw

Make your next move.

Correction to: Term birth weight and ambient air pollutant concentrations during pregnancy, among women living in Monroe County, New York (Journal of Exposure Science & Environmental Epidemiology, (2019), 29, 4, (500-509), 10.1038/s41370-019-0131-8)