David G. DeNardo

Washington University School of Medicine

United States

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Articles (13)

Year:

2024

Year:

2024

Summary PD1-blockade combinations in pancreatic ductal adenocarcinoma have been poorly effective, and the underlying reasons for this are unknown. A recent study revealed that chemoradiation plus PD1-blockade reinvigorates tumor-specific T cells; however, this T-cell activation is accompanied with exaggerated NFκB signaling, which may limit productive tumor-controlling immunity. See related article by Ali et al., p. 542

Year:

2023

Year:

2021

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2021

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2021

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2020

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2020

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2020

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2020

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2020

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2020

Year:

2020

Collaborators (17)

Sung Hoon Cho

Research assistant professor

Vanderbilt University Medical Center

UNITED STATES

David G. DeNardo

Research Interests

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Articles (13)

“RIPping” off Pancreas Cancer's Blockage of Immune Surveillance

Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough

Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors.

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors.

Rethinking immune checkpoint blockade: Beyond the T cell

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity

A framework for advancing our understanding of cancer-associated fibroblasts.

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer

Collaborators (17)

Sung Hoon Cho

Carl DeSelm

Ashley Laughney

Anna Vilgelm

Scott Powers

Sunil Hingorani

Siyuan Zhang

Deanna Edwards

Igor Astsaturov

Wenbao Yu

Siri Strand

Qingfei Wang

Hao Wu

James Alexander Nathan

Samuel Lee

Erik Sahai

Damir Sudar

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