David Hughes

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University of St. Andrews

United Kingdom

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Recent Grants

Grant: Close

Investigating the mechanisms underlying the antiviral activity of ISGylation

Open Date: 2018-10-01

Close Date: 2021-09-01

Grant: Close

Posttranslational control of our innate immune response: exploring a novel role for ISGylation.

Open Date: 2018-05-01

Close Date: 2021-04-01

Articles (12)

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2021

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2021

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2020

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2020

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2020

Collaborators (9)

Benjamin Hale

Associate Professor

University of Zurich

SWITZERLAND

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Michael Huber

Head Diagnostics and Development

University of Zurich

SWITZERLAND

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Edward Roberts

University of Glasgow

UNITED KINGDOM

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John McLauchlan

Professor

MRC-University of Glasgow Centre For Virus Research

UNITED KINGDOM

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Christina Paulus

University of St. Andrews

UNITED KINGDOM

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Richard Randall

University of St. Andrews

UNITED KINGDOM

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Chen-Hsuin Lee

University of Edinburgh

UNITED KINGDOM

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Adrian Whitehouse

Professor of Molecular Virology

University of Leeds

UNITED KINGDOM

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Stephen Goodbourn

Professor

St George’s, University of London

UNITED KINGDOM

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David Hughes

Research Interests

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Contact this professor

Recent Grants

Articles (12)

Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11

ISG15-dependent stabilisation of USP18 is necessary but not sufficient to regulate type I interferon signalling in humans

Single-cycle parainfluenza virus type 5 vectors for producing recombinant proteins, including a humanized anti-V5 tag antibody

K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication

Highly sensitive reporter cell line for detection of interferon types I–III and their neutralization by antibodies

CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection

Persistent paramyxovirus infections

Does the Zinc Finger Antiviral Protein (ZAP) Shape the Evolution of Herpesvirus Genomes?

Discovering antiviral restriction factors and pathways using genetic screens

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells

Innate intracellular antiviral responses restrict the amplification of defective virus genomes of parainfluenza virus type 5

The BHLF1 locus of Epstein-Barr virus contributes to viral latency and B-cell immortalization

Collaborators (9)

Benjamin Hale

Michael Huber

Edward Roberts

John McLauchlan

Christina Paulus

Richard Randall

Chen-Hsuin Lee

Adrian Whitehouse

Stephen Goodbourn

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