David Lane

Professor

Karolinska Institutet

Sweden

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David Lane is a Professor at the Karolinska Institute in Sweden. His research focuses on the role of mutant p53 in cancer biology, exploring topics such as gain-of-function mutations, protein stabilization, and the interaction of cancer cells with their microenvironment. His recent articles contribute to understanding the complexities of p53 mutations and protein folding in various cellular contexts.

Articles (5)

Year:

2024

Year:

2023

Year:

2023

Year:

2021

Year:

2021

Collaborators (4)

Chester Lee Drum

SINGAPORE

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Manjunatha Kini

Professor

National University of Singapore (NUS)

SINGAPORE

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Mathias Winterhalter

Professor of Biophysics

Jacobs University Bremen gGmbH

GERMANY

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Tomer Cooks

ISRAEL

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David Lane

Research Interests

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Articles (5)

Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion?

Proteasome inhibitor bortezomib stabilizes and activates p53 in hematopoietic stem/progenitors and double-negative T cells in vivo

Covalent Rescue of Mutant p53

A general approach to protein folding using thermostable exoshells

Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment

Collaborators (4)

Chester Lee Drum

Manjunatha Kini

Mathias Winterhalter

Tomer Cooks

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