David M Virshup

Professor, Program Director

Duke-NUS Medical School

Singapore

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About

David M Virshup is a Professor and Program Director at Duke-NUS Graduate Medical School, Singapore. His research primarily focuses on Wnt signaling pathways, post-translational modifications, and their implications in cancer biology. Recent publications explore the interaction of telocytes with intestinal stem cells, the regulation of protein stability, and the molecular mechanisms of cancer-related mutations.

Articles (15)

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2025

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2024

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2024

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2024

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2024

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (9)

Sally Rogers

Senior Lecturer

University of Exeter

UNITED KINGDOM

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Nicholas Jin Hong Tan

SINGAPORE

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Kris Wood

Assistant Professor

Duke University

UNITED STATES

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Kyle Wedgwood

Associate Professor

University of Exeter

UNITED KINGDOM

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GIACOMO PARISI

Istituto Italiano di Tecnologia

ITALY

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Benjamin Evans

University of Bristol

UNITED KINGDOM

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Steffen Scholpp

Professor of Cell and Developmental Biology

University of Exeter

UNITED KINGDOM

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Babita Madan

Asst. Professor

Duke-NUS Medical School

SINGAPORE

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NATHAN HARMSTON

Lecturer

Cardiff University

UNITED KINGDOM

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David M Virshup

Research Interests

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About

Articles (15)

Telocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1

Hierarchical and scaffolded phosphorylation of two degrons controls PER2 stability

Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer

A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models

Functional regulation of Wnt protein through post-translational modifications

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway

Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion

Structural model of human PORCN illuminates disease-associated variants and drug-binding sites

YJ5 as an immunohistochemical marker of osteogenic lineage

The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition

Wnts and the hallmarks of cancer

Collaborators (9)

Sally Rogers

Nicholas Jin Hong Tan

Kris Wood

Kyle Wedgwood

GIACOMO PARISI

Benjamin Evans

Steffen Scholpp

Babita Madan

NATHAN HARMSTON

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