David Schaffer

Professor/Director

University of California, Berkeley

United States

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About

David Schaffer is a Professor and Director at the University of California Berkeley, USA. His research focuses on ocular delivery of viral vectors, AAV capsid engineering, and the application of DNA viruses in biotechnology. He has also investigated mechanosensitive processes in neural stem cells, with recent articles addressing topics such as optogenetic control of cell signaling and computationally guided AAV engineering.

Articles (18)

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2025

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2021

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2021

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2020

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2020

Collaborators (3)

Jieung Baek

University of California, Berkeley

UNITED STATES

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Adam Schieferecke

University of California, Berkeley

UNITED STATES

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Jennifer Listgarten

University of California

UNITED STATES

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David Schaffer

Research Interests

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About

Articles (18)

Nickase fidelity drives EvolvR-mediated diversification in mammalian cells

The Application of DNA Viruses to Biotechnology

Ocular Delivery of Viral Vectors for Retinal and Choroidal Vascular Diseases: A Review

Advances in AAV capsid engineering: Integrating rational design, directed evolution and machine learning

Spectrin mediates 3D-specific matrix stress-relaxation response in neural stem cell lineage commitment

Computationally guided AAV engineering for enhanced gene delivery

Substrate stress relaxation regulates neural stem cell fate commitment

Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture

Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases

Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-Associated Virus Production

Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry

Effects of Molecular Size on Resolution in Charge Detection Mass Spectrometry

Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment

Genome-wide activation screens to increase adeno-associated virus production

Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell–ECM Interactions

High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture

β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells

Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy

Collaborators (3)

Jieung Baek

Adam Schieferecke

Jennifer Listgarten

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