Davide Ortolan

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National Eye Institute

United States

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Patient and Retinal Region-specific iPSC-derived RPE Models to Study AMD

Open Date: 2021-07-01

Close Date: 2024-07-01

Articles (7)

Year:

2022

Year:

2021

Year:

2021

Year:

2021

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2020

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2020

Year:

2020

Collaborators (5)

Devika Bose

Senior Research Services Professional

University of Colorado Cancer Center

UNITED STATES

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Michela Matteoli

ITALY

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Davide Pozzi

Humanitas University

ITALY

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Roberto Chiesa

Head of the Laboratory of Prion Neurobiology

Istituto di Ricerche Farmacologiche Mario Negri IRCCS

ITALY

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Kathleen Boesze‐Battaglia

UNITED STATES

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Davide Ortolan

Research Interests

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Recent Grants

Articles (7)

Single-cell–resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration

Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity.

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.

Erratum: Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity (PLoS Pathog (2020) 16:7 (e1008654) DOI: 10.1371/journal.ppat.1008654)

Collaborators (5)

Devika Bose

Michela Matteoli

Davide Pozzi

Roberto Chiesa

Kathleen Boesze‐Battaglia

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