Dennis Brown

Professor of Medicine

Massachusetts General Hospital and Harvard Medical School

United States

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Dr. Dennis Brown is a Professor of Medicine at Massachusetts General Hospital and Harvard Medical School. His research focuses on renal physiology, specifically the mechanisms of aquaporin regulation and the role of immune cells in male fertility. Recent publications include studies on the impact of focal adhesion kinase inhibition on aquaporin-2 and the role of regulatory T cells in sperm tolerance. He is also involved in investigating the assembly and function of V-ATPase in renal epithelia.

Articles (8)

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2025

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2025

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2025

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2024

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2023

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2023

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2020

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2020

Collaborators (2)

Maria Gracia Gervasi

Research Assistant Professor

University of Massachusetts Amherst

UNITED STATES

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Sylvie Breton

Full professor

Laval University

CANADA

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Dennis Brown

Research Interests

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Articles (8)

Focal adhesion kinase inhibition induces membrane accumulation of aquaporin-2 in renal epithelial cells by actin depolymerization and endocytosis inhibition

Knockout of the V-ATPase interacting protein Tldc2 in B-type kidney intercalated cells impairs urine alkalinization

Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib

Dmxl1 Is an Essential Mammalian Gene that Is Required for V-ATPase Assembly and Function In Vivo

CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis

Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility

Aquaporin Function: Seek and You Shall Find!

Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells

Collaborators (2)

Maria Gracia Gervasi

Sylvie Breton

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