Dennis Flemming Hansen

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University College London

United Kingdom

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Recent Grants

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Characterising structure, interactions and dynamics of large molecular machines and intrinsically disordered proteins using novel carbon-detected NMR

Open Date: 2017-08-14

Close Date: 2018-08-13

Grant: Close

Development of NMR methodology to study the role of dynamics of protein side chains during complex formation

Open Date: 2016-09-01

Close Date: 2021-09-01

Grant: Close

Exploring the conformational sampling and motions of side chains in proteins

Open Date: 2016-01-01

Close Date: 2019-12-01

Grant: Close

Characterising the FVIII binding region of von Willebrand factor and N8:VWF complex formation

Open Date: 2015-01-01

Close Date: 2017-01-01

Grant: Close

The UCL Integrated NMR Centre:Bridging fine-scale analysis of macromolecules and cell physiology with high-throughput population scale metabolomics, drug target validation and biomarker development .

Open Date: 2014-09-30

Close Date: 2019-09-29

Articles (18)

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2020

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2020

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2020

Collaborators (7)

Nicolas Werbeck

Professor for Molecular Biomedicine

Hochschule Furtwangen

GERMANY

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Yuki Toyama

Project Assistant Professor

The Univeristy of Tokyo

JAPAN

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Shabaz Mohammed

University of Oxford

UNITED KINGDOM

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SOMNATH MONDAL

Assistant Research Professor

Pennsylvania State University

UNITED STATES

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John Kirkpatrick

University College London

UNITED KINGDOM

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Tim Mollner

University of Oxford

UNITED KINGDOM

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Alethea Tabor

Professor of Chemical Biology

University College London

UNITED KINGDOM

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Dennis Flemming Hansen

Research Interests

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Recent Grants

Articles (18)

The Influence of Disulfide, Thioacetal and Lanthionine‐Bridges on the Conformation of a Macrocyclic Peptide

A combined NMR and Deep Neural Network approach for enhancing the spectral resolution of aromatic side chains in proteins

Mapping the FF domain folding pathway via structures of transiently populated folding intermediates

An integrative characterization of proline cis and trans conformers in a disordered peptide

Solution-state methyl NMR spectroscopy of large non-deuterated proteins enabled by deep neural networks

Picosecond Dynamics of a Small Molecule in Its Bound State with an Intrinsically Disordered Protein

Biomolecular NMR spectroscopy in the era of artificial intelligence

Intrinsic structural dynamics dictate enzymatic activity and inhibition

Optimizing frequency sampling in CEST experiments

Towards autonomous analysis of chemical exchange saturation transfer experiments using deep neural networks

Publisher Correction: Post-translational insertion of boron in proteins to probe and modulate function

Post-translational insertion of boron in proteins to probe and modulate function

Virtual Homonuclear Decoupling in Direct Detection Nuclear Magnetic Resonance Experiments Using Deep Neural Networks

FID-Net: A versatile deep neural network architecture for NMR spectral reconstruction and virtual decoupling

Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8

Multiquantum Chemical Exchange Saturation Transfer NMR to Quantify Symmetrical Exchange: Application to Rotational Dynamics of the Guanidinium Group in Arginine Side Chains

A distal regulatory region of a class I human histone deacetylase

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

Collaborators (7)

Nicolas Werbeck

Yuki Toyama

Shabaz Mohammed

SOMNATH MONDAL

John Kirkpatrick

Tim Mollner

Alethea Tabor

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