Derek Costello

Head of Neuroscience

Dublin City University

Ireland

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About

Derek Costello is the Head of Neuroscience at University College Dublin, Ireland. His research focuses on neurotoxic mechanisms, the role of the urea cycle in neurodegeneration, and inflammatory responses in the brain. Recent publications include studies on the modulation of microglial activation and the protective effects of various compounds against neurotoxicity and behavioral dysfunction.

Articles (9)

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2025

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2025

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2025

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2025

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2024

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2023

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2022

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2021

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2020

Collaborators (1)

Gavin Stewart

Lecturer in Comparative Animal Physiology

Dublin City University

IRELAND

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Derek Costello

Research Interests

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Articles (9)

Salicylaldehyde Benzoylhydrazone Protects Against Ferroptosis in Models of Neurotoxicity and Behavioural Dysfunction, In Vitro and In Vivo

Ergolide Regulates Microglial Activation and Inflammatory-Mediated Dysfunction: A Role for the Cysteinyl Leukotriene Pathway

The Role of the Urea Cycle in the Alzheimer's Disease Brain

Aging increases UT‐B urea transporter protein abundance in brains of male mice

Modulation of Urea Transport Attenuates TLR2-Mediated Microglial Activation and Upregulates Microglial Metabolism In Vitro

Regional investigation of UT-B urea transporters in the rat brain

Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages

Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells.

Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation

Collaborators (1)

Gavin Stewart

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