Dirk Heckl

Professor (W3) and Director

Goethe University Frankfurt

Germany

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Dirk Heckl is a Professor (W3) and Director at Goethe University Frankfurt, Germany. His research focuses on the genetic and molecular mechanisms underlying various leukemias, including myeloid leukemia and pediatric acute myeloid leukemia, as well as drug resistance in triple-negative breast cancer. He has contributed significantly to the understanding of long noncoding RNAs and their roles in cancer and therapeutic targeting.

Articles (10)

Year:

2025

Year:

2023

Year:

2023

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2022

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2022

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2022

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2022

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2022

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2021

Year:

2021

Collaborators (5)

Hélène Gleitz

Assistant professor

Erasmus MC

NETHERLANDS

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Tamara Jacqueline Luck

University of Helsinki

FINLAND

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Jan‐Henning Klusmann

GERMANY

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Sergio Martinez Høyer

Karolinska Institutet

SWEDEN

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Aaron Benson Wong

Assistant Professor

Erasmus MC

NETHERLANDS

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Dirk Heckl

Research Interests

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Articles (10)

Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers.

Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus <i>MYNRL15</i>.

Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion

RUNX1 isoform disequilibrium promotes the development of trisomy 21 associated myeloid leukemia.

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

Long noncoding RNAs as regulators of pediatric acute myeloid leukemia.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma

Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome.

Collaborators (5)

Hélène Gleitz

Tamara Jacqueline Luck

Jan‐Henning Klusmann

Sergio Martinez Høyer

Aaron Benson Wong

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