Ditte Hededam Welner

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Technical University of Denmark

Denmark

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Recent Grants

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A glycosyltransferase tool kit for a sustainable chemical industry

Open Date: 2019-01-01

Close Date: 2021-12-01

Grant: Close

Engineering fluorinase enzyme for the bioproduction of new-to-Nature fluorochemicals

Open Date: 2018-12-01

Close Date: 2020-11-01

Grant: Close

Glycosyltransferases as biocatalysts for eco-friendly blue jeans

Open Date: 2016-09-01

Close Date: 2019-03-01

Grant: Close

Structural studies of the NAC plant transcription factor ANAC019 in complex with DNA

Open Date: 2007-01-01

Close Date: 2011-07-01

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Collaborators (28)

Ruben Marcel de Boer

Technical University of Denmark

DENMARK

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Birte Svensson

Technical University of Denmark

DENMARK

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Cecilie Cetti Hansen

Københavns Universitet

DENMARK

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Thomas Tørring

Aarhus University

DENMARK

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Jørgen Hansen

Chief Scientific Officer

DENMARK

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Bastien Bissaro

Aix-Marseille University

FRANCE

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Finn Lillelund Aachmann

Professor

NORWAY

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David Teze

Technical University of Denmark

DENMARK

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Onur Kırtel

Technical University of Denmark

DENMARK

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Phillip Lowe

University of St. Andrews

UNITED KINGDOM

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Anne S. Meyer

Technical University of Denmark

DENMARK

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Tobias Benedikt Alter

RWTH Aachen University

GERMANY

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Katrine Qvortrup

Technical University of Denmark

DENMARK

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Christian Kjeldsen

Technical University of Denmark

DENMARK

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Bo Pilgaard

Technical University of Denmark

DENMARK

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Folmer Fredslund

Technical University of Denmark

DENMARK

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Lei Yang

Technical University of Denmark

DENMARK

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Jens Preben Morth

Technical University of Denmark

DENMARK

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Tomas Laursen

Københavns Universitet

DENMARK

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Manuel Nieto-Domínguez

Technical University of Denmark

DENMARK

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Bruna Marques dos Santos

Københavns Universitet

DENMARK

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Rita Del Giudice

SWEDEN

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Natalia Putkaradze

Technical University of Denmark

DENMARK

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Jens Øllgaard Duus

Technical University of Denmark

DENMARK

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Brianna Lax

Technical University of Denmark

DENMARK

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Ólafur Ögmundarson

Technical University of Denmark

DENMARK

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Jesper Holck

Technical University of Denmark

DENMARK

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Charlotte Uldahl Jansen

Technical University of Denmark

DENMARK

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Ditte Hededam Welner

Research Interests

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Recent Grants

Articles (25)

Unraveling the molecular mechanism of polysaccharide lyases for efficient alginate degradation

Of Revolutions and Roadblocks: The Emerging Role of Machine Learning in Biocatalysis

Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches

Crystal structure of the sucrose phosphorylase from Alteromonas mediterranea shows a loop transition in the active site

Plant-Derived UDP-Glycosyltransferases for Glycosylation-Mediated Detoxification of Deoxynivalenol: Enzyme Discovery, Characterization, and In Vivo Resistance Assessment

Chemoenzymatic indican for light-driven denim dyeing

Glucuronan lyases from family PL7 use a Tyr/Tyr syn β-elimination catalytic mechanism for glucuronan breakdown

Enzymatic glycosylation of aloesone performed by plant UDP-dependent glycosyltransferases

A growth selection system for sucrose synthases (SuSy): design and test.

GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening.

The sugar donor specificity of plant family 1 glycosyltransferases.

A life cycle assessment of early-stage enzyme manufacturing simulations from sustainable feedstocks

Action and cooperation in alginate degradation by three enzymes from the human gut bacterium Bacteroides eggerthii DSM 20697

Glucuronan lyases from family PL7 use a Tyr/Tyr syn β-elimination catalytic mechanism for glucuronan breakdown

The function of UDP-glycosyltransferases in plants and their possible use in crop protection

Promiscuous Yet Specific: A Methionine–Aromatic Interaction Drives the Reaction Scope of the Family 1 Glycosyltransferase GmUGT88E3 from Soybean

Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-O-β-d-Glucoside

Family 1 glycosyltransferases (GT1, UGTs) are subject to dilution-induced inactivation and low chemo stability toward their own acceptor substrates

Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro

Structure-guided engineering of key amino acids in UGT85B1 controlling substrate and stereo-specificity in aromatic cyanogenic glucoside biosynthesis

Exploring the in Vitro Operating Window of Glycosyltransferase PtUGT1 from Polygonum tinctorium for a Biocatalytic Route to Indigo Dye

O-/N-/S-Specificity in Glycosyltransferase Catalysis: From Mechanistic Understanding to Engineering

Discovery of fungal oligosaccharide-oxidising flavo-enzymes with previously unknown substrates, redox-activity profiles and interplay with LPMOs

Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential

Natural product C-glycosyltransferases - a scarcely characterised enzymatic activity with biotechnological potential

Collaborators (28)

Ruben Marcel de Boer

Birte Svensson

Cecilie Cetti Hansen

Thomas Tørring

Jørgen Hansen

Bastien Bissaro

Finn Lillelund Aachmann

David Teze

Onur Kırtel

Phillip Lowe

Anne S. Meyer

Tobias Benedikt Alter

Katrine Qvortrup

Christian Kjeldsen

Bo Pilgaard

Folmer Fredslund

Lei Yang

Jens Preben Morth

Tomas Laursen

Manuel Nieto-Domínguez

Bruna Marques dos Santos

Rita Del Giudice

Natalia Putkaradze

Jens Øllgaard Duus

Brianna Lax

Ólafur Ögmundarson

Jesper Holck

Charlotte Uldahl Jansen

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