Dolores Gonzalez-Pacanowska

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Profesora de Investigación

Consejo Superior de Investigaciones Cientificas

Spain

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Recent Grants

Grant: Close

Repurposing human kinase inhibitor chemotypes for Neglected Tropical Diseases

Open Date: 2021-04-01

Close Date: 2026-03-01

Grant: Close

Role of nucleotidohydrolases in the preservation of genomic integrity in Trypanosoma brucei

Open Date: 2020-06-01

Close Date: 2023-11-01

Grant: Close

Implication of dUTPase and DCTPP1 in genomic stability and mitochondrial function. Evaluation of therapeutic potential

Open Date: 2020-01-01

Close Date: 2023-03-01

Grant: Close

Mantenimiento de la homeostasis de nucleotidos y de la integridad genomica en Trypanosoma brucei.

Open Date: 2017-01-01

Close Date: 2019-12-01

Grant: Close

Red de Investigación en Enfermedades Tropicales (RICET)

Open Date: 2017-01-01

Close Date: 2021-12-01

Articles (14)

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2023

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2020

Collaborators (2)

Miguel Navarro

Professor (Profesor de Investigación)

SPAIN

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Francisca Vicente Perez

AREA HEAD SCREENING & TARGET VALIDATION (retired)

Fundación MEDINA

SPAIN

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Dolores Gonzalez-Pacanowska

Research Interests

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Contact this professor

Recent Grants

Articles (14)

Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171

Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity.

Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi.

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in <i>Trypanosoma brucei</i>.

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251

New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity

Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in <i>Trypanosoma brucei</i>

Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)

Strasseriolides A–D, A Family of Antiplasmodial Macrolides Isolated from the Fungus <i>Strasseria geniculata</i> CF-247251

Quantitation of deoxynucleoside triphosphates by click reactions

Structure–property studies of an imidazoquinoline chemotype with antitrypanosomal activity

Collaborators (2)

Miguel Navarro

Francisca Vicente Perez

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