Donal S. O’Leary
Wayne State University School of Medicine
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Articles (1)
The powerful pressor responses from the CSAR arise via O 2 delivery versus O 2 demand imbalance. Muscle metaboreflex activation (MMA) simultaneously elicits coronary vasoconstriction (which is augmented in heart failure) and profound increases in cardiac work thereby upsetting oxygen balance. Whether MMA activates the CSAR thereby amplifying MMA responses is unknown. We observed that removal of the CSAR afferents attenuated the strength of the muscle metaboreflex in normal and subjects with heart failure.
Year:
2024
Collaborators (2)
Joseph Mannozzi
-
UNITED STATES
Jasdeep Kaur
University of Texas at Austin
UNITED STATES
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